雅博司对小儿重症肝炎合并肝性脑病的疗效分析  

Effects of ornithine-aspartate on hepatic encephalopathy after severe hepatitis in children

作　　者：陈予生 

机构地区：[1]河南潢川县人民医院小儿科,潢川465150

出　　处：《中国实用神经疾病杂志》2010年第13期27-29,共3页Chinese Journal of Practical Nervous Diseases

摘　　要：目的研究雅博司治疗小儿重症肝炎并发肝性脑病的疗效。方法 41例小儿重症肝炎并发肝性脑病病人随机分成治疗组21例,对照组20例。2组均给予去除诱因,治疗原发病,低蛋白饮食,支链氨基酸,乳果糖及护肝等内科综合治疗。治疗组在内科综合治疗基础上加用雅博司治疗。观察治疗前后症状、体征、肝功能、血氨等指标变化。结果雅博司明显改善小儿HE患者的临床症状,同时降低血氨、ALT、T-Bil,神志改善明显优于对照组,差异有显著性(P<0.05)。结论雅博司在治疗小儿重症肝炎合并肝性脑病具有明显疗效,且无不良反应。Objective To study the efficacy of ornithine aspartate in the treatment of hepatic encephalopathy （HE） after severe hepatitis in children. Methods Forty-one children with severe hepatitis complicated by HE were classified into 2 groups, including treatment group （n= 21） and control group （n= 20）. In both groups, patients had comprehensive treatment with removal of etiologies, primary disease, low-protein diet, branched-chain amino acids, lactulose and protective hepatic function. In treatment group, patient received additional treatment with ornithine-aspartate injection, while control group had just routine treatment. Clinical symptoms, signs, liver functional parameters, serum ammonia were observed in both groups after treatment. Results Ornithine-aspartate could significantly improve HE in children with severe hepatitis, and decreased serum ammonia, ALT, T-Bil and consciousness （P〈 0.05）. Conclusion Ornithine-aspartate is effective to treat HE after severe hepatitis and has low side-effects.

关 键 词：儿童 重症肝炎 肝性脑病 雅博司 

分 类 号：R747.9[医药卫生—神经病学与精神病学]