136例急性脑梗死患者颈动脉粥样硬化斑块与血瘀证的相关性研究  

Association Between Carotid Atherosclerotic Plaque and Blood Stasis Syndrome in Patients with Acute Cerebral Infarction

作　　者：李林森[1,2] 田金洲[2] 蔡艺灵[3] 时晶[2] 邢亚楠[3] 孙文军[2] 

机构地区：[1]中央民族大学中国少数民族传统医学研究院,北京100081 [2]北京中医药大学东直门医院老年病科,北京100700 [3]中国人民解放军第306医院神经内科,北京100101

出　　处：《辽宁中医杂志》2010年第7期1185-1188,共4页Liaoning Journal of Traditional Chinese Medicine

基　　金：国家重点基础研究发展计划(973计划)资助项目(2003CB517104)

摘　　要：目的:探讨脑梗死患者动脉粥样硬化斑块与血瘀证的相关性。方法:对来源于中国人民解放军第306医院的136例脑梗死患者及73例非脑梗死的对照人群进行中医证候要素评分,同时采用双功能彩色多普勒超声检测双侧颈动脉内-中膜厚度(IMT)和斑块的形态、数量、回声特征。结果:在总体人群中,不规则型斑块中血瘀证所占的百分比较非血瘀证增高(P<0.05);在脑梗死患者中,血瘀证组颈动脉斑块不匀质、不规则率高于非血瘀证组(P<0.05)。相关性研究结果显示总体人群血瘀证与颈动脉斑块形态呈正相关(P<0.05)。脑梗死血瘀证与斑块数目、性质呈正相关(P<0.05)。结论:血瘀证与颈动脉粥样硬化斑块形态及数目存在正相关,且其斑块具有不稳定性。在发生脑梗死时,斑块数目增加,不稳定性增高。Objective：To investigate the blood stasis syndrome（BSS） defined by traditional Chinese medicine in cerebral infarction and its correlations with carotid atherosclerotic plaque（CAP）.Methods：All subjects comprised 136 patients with acute ischemis stroke and 73 people without acute ischemis stroke,which were based on Diagnostic Criteria for Cerebral Vascular Diseases in 2005.Diagnosis for syndromes defined by traditional Chinese medicine were made according to Diagnostic Criteria for Stroke in 1994.Patients and volunteers were examined with color dopplor ultrasound for IMT and plaque of carotid artery.Results：The frequency of ulcerative CAP in BSS group is higher than NBSS group（P〈0.05）.The frequency of ulcerative and heterogeneous CAP in patients with BSS and CI are more than those patients without BSS have CI（P〈0.05）.There is correlation between the quantity of CAP,ulcerative CAP and BSS in patients with cerebral infarction（P〈0.05）

关 键 词：脑梗死 血瘀证 动脉粥样硬化斑块 

分 类 号：R743.33[医药卫生—神经病学与精神病学]