雌激素相关受体alpha特性抑制剂XCT-790对细胞糖代谢的影响  

作　　者：杨冰 王海彬[2] 梁笃 王军舰[3] 方芳[3] 高明慧[3] 刘文明[3] 周曦[3] 

机构地区：[1]广州市越秀区正骨医院,510045 [2]广州中医药大学第一附属医院骨三科,510405 [3]中国科学院广州生物医药与健康研究院,510530

出　　处：《当代医学》2010年第18期24-25,共2页Contemporary Medicine

摘　　要：目的探讨雌激素相关受体α(ERRα)特异性抑制剂XCT-790对细胞糖代谢的影响。方法采用同位素示踪技术检测XCT-790对细胞糖酵解和糖吸收的影响,实时定量PCR检测XCT-790对糖代谢相关基因表达的影响。结果 ERRα特异性抑制剂XCT-790可以显著地增加细胞的糖酵解和糖吸收,并降低ERRa靶基因SDH和Nduf表达,增加糖代谢相关基因Tigar的表达。结论 ERRα特异性抑制剂XCT-790可以显著地增加癌细胞糖酵解和糖代谢。Objective To explore the effect of estrogen related receptor alpha specific antagonist XCT-790 on the cell glucose metabolism.Methods Cell glycolysis rate and glucose uptake was detected by isotope tracer technique,and Real Time PCR was employed to assay the expression of genes involved in cell glucose metabolism.Results Results showed that XCT-790 greatly increased the glycolysis rate and glucose uptake.In addition,XCT-790 decreased the expression of SDH and Ndufa while increased the expression of Tigar.Conclusion estrogen related receptor alpha specific antagonist XCT-790 greatly increased the cancer cell glycolysis rate and glucose uptake.

关 键 词：雌激素相关受体alpha 糖酵解 糖吸收 XCT-790 

分 类 号：R734.2[医药卫生—肿瘤]