31例慢性重型肝炎患者胰岛素生长因子-I的动态观察  

Dynamic observation on 31 insulin-like growth factor-1 cases of chronic severe hepatitis

作　　者：毕炳炎 

机构地区：[1]陕西省铜川市人民医院,727000

出　　处：《中国临床实用医学》2010年第7期22-23,共2页China Clinical Practical Medicine

摘　　要：目的探讨慢性重型肝炎患者胰岛素生长因子-1（IGF-1）的变化与病情的关系。方法用化学发光法检测31例慢性重型肝炎患者IGF-1的动态变化，并比较生存患者和死亡患者的IGF-1变化。结果慢性重型肝炎患者IGF-1变化与凝血酶原活动度（PTA）的变化相一致。生存患者IGF-1在达到一个最低值后随着PTA的增高而增高；死亡患者的IGF-1则进行性降低，在死亡前达极低值。生存患者与死亡患者IGF-1、TBiL、PTA差异有统计学意义。结论慢性重型肝炎患者IGF-1明显降低，而且与PTA的变化有相关性，动态观察慢性重型肝炎患者IGF-1的变化可作为判断病情的指标之一。Objective To study the relationship between the IGF-1 changes of chronic severe hepatitis and the development of disease. Methods Using Chemiluminescence method detects the IGF-1 dynamic variety of 31 cases of chronic severe hepatitis. The IGF-1 of survival cases and dead cases were compared. Results The varieties of IGF-1 of chronic severe hepatitis cases were consistent with the varieties of PTA. After the IGF-1 of survival cases arrived at the lowest degree, the increasing degree of IGF-1 was couple with the variety of PTA. But the IGF-1 of dead cases were consecutively decreasing and arriving at the lowest degree before death. There was significant variability in IGF-1, Thil and PTA between the survival cases and the dead cases. Conclusion The IGF-1 of chronic severe hepatitis show marked decreasing and relating with the variety of PTA. The dynamic observation of IGF-1 can be one of the indicators on disease development.

关 键 词：慢性重型肝炎 胰岛素生长因子-1 

分 类 号：R575.1[医药卫生—消化系统]