口腔粘膜扁平苔藓患者口腔多部位幽门螺杆菌的检测及其意义  

作　　者：金早蓉 宋斌 李曙霞[2] 方红辉 

机构地区：[1]暨南大学第二临床医学院深圳市人民医院口腔医学中心,518000 [2]首都医科大学附属北京口腔医院牙周粘膜科,100050 [3]暨南大学第二临床医学院深圳市人民医院检验科,518000

出　　处：《当代医学》2010年第19期1-3,共3页Contemporary Medicine

基　　金：深圳市科技计划项目(医药卫生类;编号200703102)

摘　　要：目的探讨口腔粘膜扁平苔藓与幽门螺杆菌的关系。方法根据Hp的16rRNA特异基因片段设计引物,以确诊的40例OLP患者为研究对象,收集舌背粘膜、后牙颊粘膜、后牙龈下牙菌斑、口腔含漱液及活检之石蜡包埋病理切片等多部位样本,以20例健康人群为对照,PCR法检测各样本的Hp阳性率情况。结果 40例OLPHp检出率分别为:舌背粘膜(25%)、后牙颊粘膜(32.5%)、后牙龈下牙菌斑(50%)、口腔含漱液(55%)及活检之石蜡包埋病理切片(32.5%),与对照组比较均有显著性差异(P<0.05)。糜烂型与非糜烂型OLP患者之间,活检标本Hp阳性率有显著差异(P<0.05),其它部位样本无显著性差异(P>0.05);不同性别OLP患者之间,Hp阳性率亦无显著性差异(P>0.05)。结论口腔粘膜扁平苔藓与幽门螺杆菌感染有一定潜在联系。Objective To study the correlation between Helicobacter pylori and oral lichen planus. Methods 40 patients with OLP and 20 healthy people were recruited,5 samples（respectively from touge、 buccal mucous membrane、 subgingival plaque of posterior tooth、mouth washing and one anatomy tissue）were collected from each subject for Hp detection with PCR assay. Results Positive percentages of Hp from OLP patients were all significantly higher than those from healthy people（P〈0.05）.There were no statistically significant diferrence either between erosive and non-erosive OLP patients（expect samples from anatomy tissue）,or between male and female patients（P〉0.05）.Conclusion There was a certain correlation between OLP and Hp infection.

关 键 词：口腔粘膜扁平苔藓 幽门螺杆菌 PCR 

分 类 号：R781.5[医药卫生—口腔医学]