小剂量粒细胞集落刺激因子治疗急性白血病化疗所致白细胞减少的疗效观察  

OBSERVATION OF USING LOW DOSE G CSF FOR THE LEUKOCYTEPENIE IN ACUTE LEUKEMIA CHEMOTHERAPY

作　　者：李晶[1] 孙苏玲[1] 罗鸣[1] 黄非[1] 金蓉珍[1] 

机构地区：[1]镇江医学院附属医院

出　　处：《白血病》1999年第1期14-15,共2页

摘　　要：目的研究小剂量ｒｈＧ－ＣＳＦ对急性白血病（ＡＬ）联合化疗后白细胞减少的治疗作用。方法对ＡＬ化疗后外周血白细胞显著减少，中性分叶核绝对值＜０．５×１０９／Ｌ，且伴有发热和感染者，给予ｒｈＧ－ＣＳＦ７５μｇ／ｄ，皮下注射，共３ｄ～７ｄ。同时给予抗感染治疗。结果小剂量ｒｈＧ－ＣＳＦ治疗后，白细胞在短期内升高，有效率达８７．３％，显著高于对照组（Ｐ＜０．０１）。且ｒｈＧ－ＣＳＦ组感染的持续时间较对照组短（Ｐ＜０．０１）。结论小剂量ｒｈＧ－ＣＳＦ能有效地促进ＡＬ化疗后外周血白细胞的恢复，有利于及时控制感染。Objective To study the role of low dose G CSF for the leukocytepenia in acute leukemia chemotherapy. Methods Acute leukemia patients of leukocytopenia in chemotherapy asbolute neutrophil count(≤0.5×10 9/L), complication of fever and infection were treated by low dose G CSF (75 μg/d 3～5 days). Results Low dose G CSF could increase granulocyte rapidly. The effective rate was 87.3% significantly higher than that in controls( P <0.01). The total duration of infections was significantly reduced from 9.8 to 4.8 days per patient( P <0.01). Conclusion Low dose G CSF administered in hypodermic injection between chemotherapy courses markedly increased granulocyte and shortened duration of infections.

关 键 词：急性 白血病 白细胞减少 RHG-CSF 治疗 

分 类 号：R733.710.5[医药卫生—肿瘤]