Ⅳ型胶原酶与肝细胞癌侵袭转移性的关系  

Relationship between type Ⅳ collagenase and the invasion and metastasis of hepatocellular carcinoma

作　　者：卜文[1] 汤钊猷[1] 叶胜龙[1] 刘康达[1] 黄晓武 高冬梅 

机构地区：[1]上海医科大学中山医院肝癌研究所

出　　处：《中华消化杂志》1999年第1期13-15,共3页Chinese Journal of Digestion

基　　金：上海市医学领先学科基金;美国中华医学基金会基金

摘　　要：目的揭示Ⅳ型胶原酶与肝细胞癌（ＨＣＣ）侵袭转移性的关系。方法通过明胶酶谱法对ＨＣＣ癌、癌旁肝组织及血浆中Ⅳ型胶原酶含量进行测定，并与反映ＨＣＣ侵袭转移性的病理指标进行统计学分析。结果ＨＣＣ及其癌旁肝组织均有Ⅳ型胶原酶表达；ＨＣＣ组织中Ⅳ型胶原酶含量升高及基质金属蛋白酶２（ＭＭＰ２）活性形式的出现与ＨＣＣ侵袭转移性有关；血浆中Ⅳ型胶原酶含量的升高与ＨＣＣ侵袭转移有关。结论Ⅳ型胶原酶与ＨＣＣ侵袭转移性有关。Objective To achieve the insights into the relationship between type Ⅳ collagenase and the invasion and metastasis of hepatocellular carcinoma (HCC). Methods Zymography was used to study the type Ⅳ collagenase content in the HCC, and statistics were made to analyze the association between the content of type Ⅳ collagenase and the invasive and metastatic indexes of HCC.Results Type Ⅳ collagenase existed in all HCC tumor, surrounding liver parenchyma and the plasma; the increase of type Ⅳ collagenase and the presence of active MMP 2 were related to the invasiveness and metastasis of HCC; the increase of plasma type Ⅳ collagenase was also related to the invasion and metastasis of HCC.Conclusion Type Ⅳ collagenase is related to invasion and metastasis of HCC.

关 键 词：金属蛋白酶 细胞外基质 肝细胞癌 肿瘤侵袭 

分 类 号：R735.702[医药卫生—肿瘤]