幼年特发性关节炎全身型血清铁蛋白的水平变化及临床意义  

The Change and Clinical Significance of Serum Ferritin in Systemic Onset Juvenile Rheumatoid

作　　者：叶春风[1] 刘洋[1] 刘燕玲[1] 李国林[1] 宋小华[1] 

机构地区：[1]南昌大学第二附属医院儿科,南昌330006

出　　处：《南昌大学学报（医学版）》2010年第4期77-79,共3页Journal of Nanchang University：Medical Sciences

摘　　要：目的探讨血清铁蛋白(serumferritin,SF)在幼年特发性关节炎全身型(systemonset juvenileidiopathic ar-thritis,SoJIA)的水平变化及临床意义。方法采用化学发光法检测SoJIA组患儿(n=30)在治疗前活动期和治疗后病情缓解期SF水平的变化;同时检测感染性疾病组(n=30)、肿瘤组(n=30)及其他结缔组织病组(n=30)患儿的SF水平。结果 SoJIA组、感染性疾病组、肿瘤组及其他结缔组织病组患儿的血清SF水均升高;SoJIA组活动期血清SF水平显著高于其他3组(均P<0.01);SoJIA组活动期SF水平明显高于缓解期(P<0.01)。结论 SF是诊断SoJIA有价值的实验室指标,并可为病情活动期及疗效观察提供依据。Objective To investigate the evolution of serum ferritin levels in children with system onset juvenile idiopathic arthritis（SoJIA） at the time of clinical significance.Methods 30 children with SoJIA were tested before and after treatment,total serum ferritin levels were detected by Chemiluminescence,the same as serum ferritin levels of infectious diseases groups（n= 30）,tumor groups（n=30） and other connective tissue disease groups（n= 30） were determined.Results Total serum ferritin levels remained high in SoJIA,infectious diseases,tumor and other connective tissue disease groups.The serum ferritin levels in active SoJIA patients were higer than those in control subjects（P〈0.01）as well as the serum ferritin levels in active SoJIA patients were higer than those in inactive SoJIA patients（P〈0.01）.Conclusions Serum ferritin is a valuable marker as a diagostic tool in suspected SoJIA and it is a marker that provide foundation with disease activity and observing treatment.

关 键 词：血清铁蛋白 幼年特发性关节炎 全身型 

分 类 号：R726.8[医药卫生—儿科]