甘丙肽受体新配基的合成  

Synthesis of Novel Galanin Receptor Ligands

作　　者：毛杨[1] 孟庆国[1] 梁月洁[1] 王亮[1] 孙海军[1] 

机构地区：[1]烟台大学药学院,山东烟台264005

出　　处：《烟台大学学报（自然科学与工程版）》2010年第3期194-197,共4页Journal of Yantai University(Natural Science and Engineering Edition)

基　　金：烟台大学博士启动基金(YX04B18)

摘　　要：基于目标化合物的结构和液相肽片段合成方法的优点,设计采用液相合成方法,以混合酸酐法使羧基和氨基缩合,经缩合、脱除Fmoc保护基、缩合、脱除Boc保护基4步反应,共合成了5个中间体和3个新甘丙肽受体新配基,目标化学物和部分中间体的结构经1H NMR或MS确证.所有反应均在温和条件下进行,操作简便,收率较高.Based on the structure of the objective compounds and the advantages of fragmentary peptide synthesis in liquid phase,the mixed anhydride method is designed and used in the synthesis of new Galanin receptor ligands.The synthetic procedure includes condensation,deprotection of Fmoc group,condensation,and deprotection of Boc group.Three new objective compounds and five intermediates are prepared,of which the structures are determined by 1H NMR or ESI-MS.All reactions can be held conveniently under mild conditions and in high yield.

关 键 词：甘丙肽 甘丙肽受体 配基 合成 

分 类 号：R914[医药卫生—药物化学]