姜黄醇提取物对兔食饵性高脂血症的实验研究  

Experimental Study about the Extracts of Turmerol in Dietary Rabbit with Hyperlipemia

作　　者：沃兴德[1] 高承贤[1] 洪行球[1] 李万里[1] 金明敏[1] 唐利华[1] 丁志山[1] 王亚丹[1] 

机构地区：[1]浙江中医学院分子医学研究所,杭州310009

出　　处：《浙江中医学院学报》1999年第1期16-18,共3页Journal of Zhejiang College of Traditional Chinese Medicine

基　　金：国家中医药管理局科研基金!92B049

摘　　要：用高脂饲料、含血脂康和三种剂量姜黄醇提取物的饲料喂饲日本大耳兔，4周、9周和12周处死测定脂质代谢变化，发现喂饲高脂膳食血清胆固醇和甘油三酯增高，HDL－C降低，主动脉和肝脏中脂质含量明显增高，并且随喂饲时间延长病情加重。加服血脂康9周后才使血清胆固醇和甘油三酯降低，HDL－C增高，12周处死后发现对肝脏中的胆固醇和甘油三酯作用不明显，部分动物主动脉壁粥样硬化病变减轻。加服姜黄醇提取物4周即明显地降低血清甘油三酯和增高HDL－C，并且呈量效关系。降低血清胆固醇作用在9周后出现，12周处死后发现姜黄醇提取物亦能显著地降低肝脏中胆固醇和甘油三酯含量，以及减轻主动脉里粥样硬化病变，实验证实血脂康和姜黄醇提取物均能显著地降低血清胆固醇和甘油三酯含量，血脂康以降胆固醇为主，姜黄醇提取物以降甘油三酯为主。Some Japanese big-eared rabbits are fed with the forage including high fat, Xue Zhi Kang and three doses of turmerol extracts, measure the metabolic change of lipid after killing them at four weeks, nine weeks and twelve weeks respectively, it's found that the rabbits with high-fat diet have high serum cholesterol and triglyceride, low HDL-C, the contents of lipid in the aorta and liver increase obviously, and the longer the feeding time is, the severer the state of illness gets. Only having been added Xue Zhi Kang to them for 9 weeks, are the serum cholesterol and triglyceride made lower, and HDL-C higher. After 12 weeks they are executed, there are no clear changes of cholesterol and triglyceride in the liver, however the atheromatous sclerosis in aortic wall lessens. Adding turmerol extracts for 4 weeks, the serum triglyceride obviously lowers, while HDL-C rises, they are dose-effect in relationship. At 9 weeks, the serum cholesterol begins to lower, 12 weeks later, after execution, the turmerol extracts also can distinctly reduce the contents of cholesterol and triglyceride in the liver and lessen the pathologic change of atheromatous sclerosis in aortic wall. The experiment proves that Xue Zhi Kang and turmerol extracts both can markedly reduce the contents of serum cholesterol and triglyceride, Xue Zhi Kang mainly reduces cholesterol, and turmerol extracts reduces triglyceride.

关 键 词：姜黄醇提取物 高脂血症 动物实验 高脂饮食 

分 类 号：R589.205[医药卫生—内分泌] R965[医药卫生—内科学]