同病异治复方对三种不同急性癫痫模型的药效学观察  

The same disease with different treatment compound on three different models of acute epilepsy, pharmacodynamics observed

作　　者：谢炜[1] 汪珍珍[1] 赵云燕[1] 于云红[1] 鲍勇[1] 

机构地区：[1]南方医科大学南方医院,广东广州510515

出　　处：《中医药导报》2010年第7期4-7,共4页Guiding Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家中医药管理局中医药科学技术研究专项(06-07JP34);广东自然基金课题(07002548);广东省中医药局科研课题(2007116);广东省科技计划课题(2007B080701015);广东省科技计划课题(2008B080701028)

摘　　要：目的:观察及比较中医从痰论治复方和从肝论治复方的抗癫痫疗效。方法:60只Wistar大鼠被随机分为6组,即模型组(A组),丙戊酸钠组(B组),柴胡疏肝汤低、中、高剂量组(C组、D组、E组),定痫丸组(F组),试验大鼠戊四氮(PTZ)急性癫痫模型。120只昆明小鼠被随机分为6组,分组同上,分别试验小鼠最大电休克(MES)和小鼠士的宁急性惊厥模型。结果:C组、D组、E组、F组和B组可显著延长PTZ急性癫痫大鼠发作性阵挛的潜伏期(P<0.05);MES模型中,D组、E组、F组和B组的小鼠惊厥率较A组低;在士的宁惊厥小鼠模型中,柴胡疏肝汤D组、E组、F组和B组的小鼠惊厥率和死亡率都较A组低。结论:癫痫从肝论治复方和从痰论治复方均具有抗惊厥、抗癫痫的作用。Objective： To observe and compare the antiepileptie effect of TCM treatment compound from the sputum and from the liver.Methods： 60 Wistar rats were randomly divided into 6 groups, namely, the model group （A group）, sodium valproate group （B group）, Shugan Tang low, medium and high dose group （C group, D group, E）, fixed Pill group （F group）, experimental rat pentylenetetrazol（PTZ） model of acute epilepsy.120 mice were randomly divided into 6 groups, group ibid, respectively, the maximum electric shock test in mice（MES） and strychnine in mice model of acute seizures.Results： C group, D group, E group, F group and B group could significantly prolong the onset of PTZ clonic epileptic rats with acute incubation period （P〈0.05）; MES model, D group, E group, F group, and BGroup A mice were lower than the seizure rate; strychnine convulsions in the mouse model, Shugan Tang D group, E group, F group and B group of mice convulsions and death rates are lower than the A group.Conclusion： Epilepsy from liver and from the sputum of compound treatment with the com- pound are anticonvulsant, antiepilcptic role.

关 键 词：癫痫 同病异治 从痰论治 从肝论治 柴胡疏肝汤 定痫丸 

分 类 号：R285.5[医药卫生—中药学]