Supported by National Natural Science Foundation of China:Molecular Mechanism Underlying the Intervention of Scorpion Extract BmK IT2 on Epileptogenesis via Voltage-gated Nav1.6 Channels in Hippocampal Neurons(No.81903995);Molecular Mechanism Underlying the Intervention of Scorpion Polypeptide MarTX on Temporal Lobe Epileptogenesis by Inhibiting Mechanosensitive Channel Piezo1(No.82074162);Youth Talent Promotion Project of China Association of Chinese Medicine(No.CACM-2019-QNRC2-C10);Project for Capacity Promotion of Putuo District Clinical Special Disease(Stroke,2019tszb02);Science and Technology Innovation Project of Putuo District Health System:Molecular Mechanism of Aerobic Exercise Intervention on Post-epileptic Depression Through"Bone-brain Axis"(No.ptkwws202107);the Antiepileptic Mechanism of Scorpion Active Extract BmK AS Regulating Nav1.6 Sodium Channel in Hippocampal Pyramidal Neurons(No.ptkwws201902);Evaluation of Microglial Lysosomal BK Channels as Molecular Targets for Clinical Treatment of Temporal Lobe Epilepsy(ptkwws201908);Molecular Mechanism of Sodium Channel SCN8A(Nav1.6)Mutation Mediating Epilepsy and Sodium Valproate Resistance in Children the Research Project of Putuo Hospital,Shanghai University of Traditional Chinese Medicine(No.2019308),(No.2019307)。
OBJECIVE:To investigate the efficacy and mechanisms of Dingxian pill(定痫丸)combined with valproic acid(VPA)on pentylenetetrazol-induced chronical epilepsy in rats.METHODS:A rat model of epilepsy was established by ad...