定痫丸联合吡仑帕奈治疗成人局灶性癫痫临床研究  

Clinical Study of Dingxian Pills Combined with Perampanel in the Treatment of Adult Focal Epilepsy

作　　者：王丹[1] 李平[1] 陈云[1] 张雪意 陈延 郭珍立[1] WANG Dan;LI Ping;CHEN Yun;ZHANG Xueyi;CHEN Yan;GUO Zhenli(Department of Neurology,Hubei Provincial Hospital of Integrated Traditional Chinese and Western Medicine(formerly Xinhua Hospital of Hubei Province),Wuhan 430015,China;Department of Neurological Function-EEG Room,Hubei Provincial Hospital of Integrated Traditional Chinese and Western Medicine(formerly Xinhua Hospital of Hubei Province),Wuhan 430015,China)

机构地区：[1]湖北省中西医结合医院(原湖北省新华医院)神经内科,武汉430015 [2]湖北省中西医结合医院(原湖北省新华医院)神经功能科-脑电图室,武汉430015

出　　处：《中西医结合研究》2023年第1期13-17,共5页Research of Integrated Traditional Chinese and Western Medicine

基　　金：湖北省卫生健康委中医药科研立项面上项目(No.ZY2021M025)。

摘　　要：目的探讨定痫丸联合吡仑帕奈治疗成人局灶性癫痫的临床疗效及安全性。方法选择70例局灶性癫痫患者作为研究对象,将其随机分成治疗组(n=35)与对照组(n=35)。对照组仅给予吡仑帕奈片治疗,治疗组给予中药定痫丸联合吡仑帕奈片治疗。比较2组治疗3个月和6个月后的癫痫发作频率和持续时间、血清炎症因子及脑电图变化,并比较2组临床疗效和药物不良反应。结果治疗3个月和6个月后,治疗组总有效率均显著高于对照组(42.86%vs.22.86%,57.14%vs.37.14%;P<0.05);2组癫痫发作频率和持续时间均较治疗前明显降低(P<0.05),且治疗组均显著低于对照组(P<0.05)。治疗6个月后,2组血清白介素-1β(interleukin-1β,IL-1β)、白介素-6(interleukin-6,IL-6)、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)水平均较治疗前降低(P<0.05),且治疗组上述指标显著低于对照组(P<0.05)。2组脑电图重度异常占比均较治疗前下降(P<0.05),且治疗组显著低于对照组(P<0.05)。2组不良反应总发生率组间比较,差异无统计学意义(P>0.05),但治疗6个月后的不良反应总发生率均较治疗3个月后增加(P<0.05)。结论定痫丸联合吡仑帕奈治疗局灶性癫痫能减少患者癫痫发作,改善血清炎症因子,且不良反应较少,值得推广使用。Objective To explore the clinical efficacy and safety of Dingxian pills combined with perampanel in the treatment of focal epilepsy in adults.Methods Seventy patients with focal epilepsy were randomly divided into treatment group(n=35)and control group(n=35).The control group was only treated with perampanel tablets,and the treatment group was treated with Chinese medicine Dingxian pills combined with perampanel tablets.The epileptic seizure frequency and duration,inflammatory factors and electroencephalogram(EEG)changes were compared in the two groups after 3 and 6 months of treatment.The clinical efficacy and adverse drug reactions were also compared in both groups.Results After 3 months and 6 months of treatment,the total effective rate in the treatment group was significantly higher than the control group(42.86%vs.22.86%,57.14%vs.37.14%;P<0.05).The frequency and duration of epileptic seizures in the two groups were significantly lower than those before treatment(P<0.05),and the treatment group was significantly lower than the control group(P<0.05).After 6 months of treatment,the levels of interleukin-1β(IL-1β),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)were all decreased than those before treatment(P<0.05),and the above indicators in the treatment group were significantly lower than the control group(P<0.05).The proportion of EEG severe abnormalities in the two groups were decreased compared with those before treatment(P<0.05),and the treatment group was significantly lower than the control group(P<0.05).The overall incidence of adverse reactions were not significant between the two groups(P>0.05),but the overall incidence of adverse reactions increased after 6 months of treatment compared with 3 months of treatment(P<0.05).Conclusion The treatment of focal epilepsy with Dingxian pills combined with perampanel could reduce seizures,improve serum inflammatory factors,and had few adverse effects.It is worthy of promotion.

关 键 词：定痫丸 吡仑帕奈 局灶性癫痫 

分 类 号：R742.1[医药卫生—神经病学与精神病学] R277.7[医药卫生—临床医学]