衰老骨骼肌中的兴奋-收缩偶联与MG29蛋白  

Effects of MG29 protein on excitation-contraction coupling in senescent muscles

作　　者：瞿惠芳[1] 潘文朝[2] 闫万军[3] 

机构地区：[1]南京艺术学院体育教研室,江苏省南京市210000 [2]廊坊职业技术学院,河北省廊坊市102800 [3]河北师范大学体育学院,河北省石家庄市050016

出　　处：《中国组织工程研究与临床康复》2010年第24期4512-4515,共4页Journal of Clinical Rehabilitative Tissue Engineering Research

基　　金：河北省教育厅自然科学研究项目资助;项目编号:Z2009129~~

摘　　要：背景:"兴奋-收缩偶联"是神经-肌肉功能的基本功能特点,在衰老过程中肌肉功能的衰退与肌细胞中的兴奋-收缩解偶联存在密切关系。近年来针对衰老肌细胞功能退化的研究有了许多新进展。目的:综述有关衰老肌细胞钙离子变化的机制以及MG29蛋白在钙离子及与兴奋-收缩偶联过程中的作用的有关文献,为进一步了解衰老骨骼肌功能退化的机制提供理论参考。方法:应用计算机检索CNKI期刊全文数据库(2000-01/2009-11)和PubMed数据库(2009-01/2009-12)与衰老肌细胞钙离子变化的机制以及MG29蛋白及兴奋-收缩偶联相关的文献,检索词分别为"兴奋-收缩偶联;肌组织;肌细胞;衰老;抗阻训练;MG29"和"excitation-contraction;muscle;muscle cell;senescence;resistance training;MG29"。纳入和衰老肌细胞钙离子、兴奋-收缩偶联及MG29蛋白相关的研究,排除陈旧的、重复的以及缺乏可信度的文献。结果与结论:初步检索到中英文文献共43篇,根据本研究的纳入排除标准,排除9篇不符合标准的文献,最终纳入34篇文献进行分析。结果发现,许多研究已经证明MG29蛋白在肌细胞兴奋-收缩偶联中起着重要的作用,而随增龄MG29会出现明显减少的规律,推断其在肌组织衰老中可能扮演重要角色。更为重要的是,新近有研究者发现适宜的抗阻训练可以使肌组织中MG29表达量增加。BACKGROUND：Excitation-contraction coupling is a basic functional feature of nerve-muscle,to some extent,which closely associates with functional deterioration of senescent muscles.Researchers have made obviously progress in this field recently.OBJECTIVE：To summarize the mechanism of the change of Ca2＋ in senescent muscle cells and the effects of MG29 protein on Ca2＋ changes and excitation-contraction coupling,and to provide reference for studying functional deterioration via reviewing related literatures.METHODS：Papers related to mechanism of the change of Ca2＋ in senescent muscle cells and correlation between MG29 protein and excitation-contraction coupling published in CNKI（2000-01/2009-11） in Chinese and in PubMed（2009-01/2009-12） in English were searched by computer based on the keywords of ＂excitation-contraction,muscle,muscle cell,senescence,resistance training and MG29＂.Obsolete,repetitive and credibility-lacking literatures were excluded. RESULTS AND CONCLUSION：Totally 43 papers were retrieved.According to the inclusive and exclusive criteria,9 papers were excluded and 34 documents were included in the final analysis.The results showed that MG29 plays an important function in excitation-contraction coupling and decreases with age increasing.Therefore,MG29 is speculated as a key factor of muscle senescence.Importantly,recent researches show that MG29 could be increased by resistance training.

关 键 词：兴奋-收缩偶联 肌组织 肌细胞 MG29 抗阻训练 衰老 

分 类 号：R318[医药卫生—生物医学工程]