粪便脱落细胞及其标志物检测筛查大肠癌的研究现状  

Study of exfoliative cells in human stool and markers of colorectal cancer screening

作　　者：孟明明[1] 李世荣[1] 

机构地区：[1]北京军区总医院消化内科,北京100700

出　　处：《胃肠病学和肝病学杂志》2010年第7期584-587,共4页Chinese Journal of Gastroenterology and Hepatology

摘　　要：近年来大肠癌发病率呈逐年上升趋势,早期大肠癌常无临床症状,需通过筛查才能发现。目前大肠癌筛查的常用方法是粪隐血试验,但它存在假阴性和假阳性过高的局限性。为了弥补其不足,人们尝试进行粪便脱落细胞及其相关标志物的检测以探讨大肠癌早期诊断的新方法,在大肠癌筛查上具有潜在的应用前景,本文对近年有关研究进展进行系统回顾。In recent years,the incidence of colorectal cancer is increasing year by year.Usually,early colorectal cancer which can be found by screening has no clinical symptoms.At present,fecal occult blood test（FOBT） is a common method of colorectal cancer screening,but the limitations of FOBT are high false negative and false positive.To make up its shortcomings,detections of exfoliative cells and relative markers were carried out to search for new methods of colorectal cancer early diagnosis.This paper will systematically review the research advances in recent years.

关 键 词：大肠癌 粪便脱落细胞 标志物 筛查 

分 类 号：R735.34[医药卫生—肿瘤]