人源幼虫巨大致死性基因在结肠癌中的表达及意义  

Expression and significance of Hugl-1 gene in colorectal cancer

作　　者：范楷[1] 董卫国[1] 王海云[1] 雷晓斐[1] 张玉[1] 

机构地区：[1]武汉大学人民医院消化内科,湖北武汉430060

出　　处：《胃肠病学和肝病学杂志》2010年第7期619-621,共3页Chinese Journal of Gastroenterology and Hepatology

摘　　要：目的研究人源幼虫巨大致死性基因Hugl-1表达与人结肠癌临床病理资料的关系,探讨Hugl-1基因表达与结肠癌肿瘤发生、侵袭的相关性。方法对99例结肠癌标本、17例正常及结肠良性病变组织应用免疫组化SP法检测Hugl-1基因的表达情况。结果结肠癌组织中Hugl-1基因表达水平显著低于正常及结肠良性病变组织(P<0.05)。结肠癌组织中Hugl-1基因表达水平与肿瘤TNM分期、淋巴结转移程度存在相关性(P<0.05),而与患者的性别、年龄及肿瘤病理分级无关。结论Hugl-1表达下降与结肠癌的发生、发展过程有关,可作为反映结肠癌恶性生物学行为的一个较有价值的指标。Objective To assess the correlation of the expression of Hugl-1（human lethal-giant larvae 1） gene with various clinicopathologic parameters in colorectal cancer.Methods The expression of Hugl-1 gene in 99 colorectal cancer and 17 colorectal benign lesion tissues was assayed by immunohistochemical SP method.Results The expression of Hugl-1 gene was significantly lower in colorectal cancer tissues than that in normal and colorectal benign lesion tissues（P0.05）.The expression of Hugl-1 was closely related to TNM stages and lymph node involvement in colorectal cancer（P0.05） and not related to sex,age and pathology classification.Conclusion Low expression of Hugl-1 in colorectal cancer may affect cell hyperplasia,and may be related to the pathogenesis and development of colorectal cancer.

关 键 词：结肠癌 人源幼虫巨大致死性基因 免疫组化 

分 类 号：R735.35[医药卫生—肿瘤]