对氧磷酶1基因多态性与原发性高血压伴颈动脉粥样硬化病变的关系  

The Association Between Paraoxonase-1 Polymorphisms and Essential Hypertension with Carotid Atherosclerosis

作　　者：赵芳[1] 徐新娟[1] 马岩萍[1] 梁晓慧[1] 张俊仕[1] 胡广梅[1] 马杰[1] 

机构地区：[1]新疆医科大学附属第一医院高血压科,新疆乌鲁木齐市830054

出　　处：《中国动脉硬化杂志》2010年第5期385-388,404,共5页Chinese Journal of Arteriosclerosis

基　　金：乌鲁木齐市科学技术项目(Y05331001)

摘　　要：目的研究对氧磷酶1基因多态性与原发性高血压伴颈动脉粥样硬化病变的关系。方法对321例高血压伴颈动脉粥样硬化病变的病例组和206例高血压颈动脉内膜正常的对照组进行研究。病例组中汉族230例,维吾尔族91例;对照组中汉族123例,维吾尔族83例。采用聚合酶链反应限制性片长多态性技术分析对氧磷酶1L55M基因多态性。结果新疆汉族高血压人群对氧磷酶1 L55M的M等位基因频率在病例组高于对照组(χ2=4.038,P=0.044);维吾尔族高血压人群中对氧磷酶1 L55M的三种基因型和等位基因频率分布在病例组与对照组间差异无统计学意义(P>0.05)。新疆汉族高血压人群中M等位基因携带者低密度脂蛋白升高,差异有统计学意义(P=0.029)。新疆汉族对氧磷酶1 M等位基因、年龄、体质指数是高血压伴发颈动脉粥样硬化病变的危险因素。结论新疆汉族高血压人群对氧磷酶1 L55M基因多态性与颈动脉粥样硬化病变有关,55M等位基因是高血压伴发颈动脉粥样硬化病变的危险因素之一,M等位基因与低密度脂蛋白升高有关。Aim To investigate the relationship between paraoxonase-1（PON1） polymorphisms and essential hypertension with carotid atherosclerosis. Methods The study comprised 527 participants who were divided into two groups： essential hypertension with carotid atherosclerosis（case group,n=321） and essential hypertension without carotid atherosclerosis（control group,n=206）.The case group was consisted of Han people（n=230） and Uighur people（n=91）.The control group was consisted of Han people（n=123） and Uighur people（n=83）.Genotypes were detected by polymerase chain reactions followed by restriction analysis with specific endonucleases and their frequencies were determined. Results The M allele frequency of the PON1 L55M gene exihibited a significant difference between case group and control group in Han people（χ2=4.038,P=0.044）.LDL exhibited a difference in Han people between LL genotype and M allele carriers（P=0.029）.The M allele might be a risk factor for carotid atherosclerosis in Han people（P=0.016）. Conclusion The single nucleotide polymorphism of PON1 L55M is probably associated with carotid atherosclerosis in essential hypertension people of Chinese Han population in Xinjiang.The M allele might be a risk factor.

关 键 词：对氧磷酶1 基因多态性 原发性高血压 颈动脉粥样硬化病变 

分 类 号：R363[医药卫生—病理学]