骨的硬纤维瘤及其治疗(附8例报告)  

Desmoplastic Fibroma of Bone

作　　者：杨荣利[1,2] 徐万鹏[1,2] 柏树亭[1,2] 姜保国[1,2] 芦仁羿 

机构地区：[1]北京医科大学人民医院骨肿瘤科 [2]北京市积水潭医院

出　　处：《中国肿瘤临床》1999年第2期133-136,共4页Chinese Journal of Clinical Oncology

摘　　要：目的：探讨骨的硬纤维瘤合理的外科治疗方法。方法：８例骨的硬纤维瘤患者，７例接受外科治疗（３例囊内切除、植骨及骨水泥填充，４例行广泛切除，人工假体置换）。结果：３例囊内切除中，除１例股骨下端３次复发后，恶变为骨肉瘤，术后２年半死于肺转移。余随访１～１２年，肿瘤无复发，邻近关节活动好。结论：骨的硬纤维瘤虽然是一种良性的肿瘤，但是具有较强的侵袭性，单纯行囊内切除，文献报道复发率可达５０％。因此。Purpose: Desmoplastic fibroma of bone is a rare benign tumor of bone. Its histopathologic feature is similar to desmoid fibroma of soft tissue, and it has strong invasiveness and easy to recur. Methods: The authors report on 8 cases treated by wide excision from 1986 to 1998 including 5 males and 3 females, with an average age of 28 years. The common site of the tumor was at the epiphyseal end of the long bone.All the patients experienced local pain or a mass for a relatively long time. Results: Surgery was not performed in one case with a huge mass and multiple lesions. Seven patients were treated by operation including 3 intracapsular excision and four wide excision. One of the three patients with tumor intracapsularly excised tumor recurred 3 times and finally turned into osteosarcoma and died of lung metastasis.There was no recurrence observed in four cases of wide excision and prosthesis. Conclusion: Wide excision is the treatment of choice. Although desmoplastic fibroma of bone is considered as benign tumor but its recurrence rate is about 50%after intracapsular excision. If wide excision is not feasible, thorough curettage of the tumor followed by alcohol or liquid nitrogen deactivation of tumor cavity is recommended.

关 键 词：骨肿瘤 硬纤维瘤 外科手术 

分 类 号：R738.105[医药卫生—肿瘤] R730.56[医药卫生—临床医学]