P物质和神经激肽1在乳癌组织的表达及意义  

EXPRESSIONS AND SIGNIFICANCE OF SUBSTANCE P AND NEUROKININ-1 IN BREAST CARCINOMA

作　　者：王继纲[1] 高涵[2] 陈桦[2] 

机构地区：[1]青岛大学医学院附属医院病理科,山东青岛266003 [2]青岛市市立医院病理科

出　　处：《齐鲁医学杂志》2010年第5期396-398,共3页Medical Journal of Qilu

基　　金：青岛市科技发展计划资助项目(08-2-1-4-nsh)

摘　　要：目的研究P物质及其受体神经激肽1(NK-1)在乳癌组织表达及意义。方法采用免疫组织化学染色法检测P物质及NK-1在乳癌以及导管上皮非典型增生、纤维腺瘤、腺病及导管内乳头状瘤等良性病变组织表达。结果 P物质和NK-1在乳癌组织阳性表达率分别为74.76%(77/103)和87.38%(90/103),二者表达水平与乳癌组织学分级呈正相关(r=0.253、0.228,P<0.05)。P物质和NK-1在5例乳腺导管上皮不典型增生组织均呈阳性,而在5例纤维腺瘤及6例腺病中均呈阴性。3例导管内乳头状瘤均未见P物质表达,而2例存在NK-1的阳性表达。结论 P物质及NK-1参与了乳癌的发病过程,为乳癌诊断提供了新的可能的免疫组化指标。Objective To investigate the expressions of substance P（SP） and neurokinin-1（NK-1） in breast cancer andevaluate their clinical significance. Methods Immunohistochemistry was used to detect the expressions of SP and NK-1 in breast carcinoma,and in benign lesions such as atypical hyperplasia in ductal epithelium（AHDE）,fibroadenoma,adenosis,and intraductal papilloma（IDP）. Results The expression rate of SP and NK-1 in breast cancer was 74.76%（77/103） and 87.38%（90/103）,respectively,the above two expressions were positively correlated with histological grading（r=0.523,0.228;P0.05）.The expressions of SP and NK-1 were positive in five cases of AHDE,but negative in five cases with fibroadenoma and six withadenosis.In three cases with IDP,no SP was found,but two were observed with NK-1 expression. Conclusion Substance P and neurokinin-1 involve in the development of breast carcinoma,which provides new and potential immunohistochemical markers for the diagnosis of breast cancer.

关 键 词：乳腺肿瘤 P物质 受体 神经激肽1 免疫组织化学 

分 类 号：R787.9[医药卫生—口腔医学]