抗凝血酶-Ⅲ抗原与活性在各类型肝炎与失代偿期肝硬化患者中的表达  

Showdown of Antithrombin-III Antigen and Active on Several Type of Hepatitis and Decom-pensation Cirrhosis

作　　者：周立红[1] 刘敏涓[1] 董临江 刘兰平[3] 刘泽霖[1] 

机构地区：[1]广州医学院第二附属医院,广州510260 [2]深圳市宝安医院 [3]广州市第一军医大学附属珠江医院

出　　处：《临床消化病杂志》1999年第1期14-15,共2页Chinese Journal of Clinical Gastroenterology

摘　　要：目的:测定各类型肝炎与失代偿期肝硬化患者血浆中抗凝血酶-Ⅲ(Antithrombin-Ⅲ,AT-Ⅲ)的含量,并探讨其临床意义。方法:AT-Ⅲ抗原(AT-Ⅲ:Ag)测定采用免疫浊度法,AT-Ⅲ活性(AT-Ⅲ:A)测定采取发色底物法。结果:AT-Ⅲ:Ag的中位数值减低见于失代偿期肝硬化组(P<0.05,AT-Ⅲ:A的中位数值减低见于失代偿期肝硬化组与慢活肝组,但各组中病例审定所见AT-Ⅲ:Ag/A减低的百分率,从高向低排列,依次为:失代偿期肝硬化(55％/70％)、慢活肝(30％/60％)、急性病毒性肝炎(35％/35％)、慢迁肝(7.9％/50％)与急性中毒性肝炎(7.1％/21.4)。结论:AT-Ⅲ减低与肝功能受损程度有关,肝病愈重,其减低率愈高。Purpose: Preliminary evaluation of clinical significance in determination of antithrombin- Ⅲ (AT-Ⅲ) levels in plasma with several type of hepatitis and decompensation cirrhosis. Methods: AT-Ⅲ antigen (AT-Ⅲ: A) was determined with immunturbidity test. AT-Ⅲ active (AT-Ⅲ : A) was determined with chromogenic peptide substrated method. Results: AT-Ⅲ: Ag was decreased in decompensation cirrho-sis, AT-Ⅲ: A were decreased in decompensation cirrhosis and chronic active hepatitis. But percent of de-crease on the AT-Ⅲ:Ag/AT-Ⅲ: A with several groups from high to low: Decompensation cirrhosis was 55 % /70 % , chronic active hepatitis was 30 %/60 %, acute virus hepatitis was 35 % /35 %, chronic persis-tent hepatitis was 7.9%/50% and acute toxinic hepatitis was 7.1%/21.4% . Conclusion: The decrease of AT-Ⅲ is always related with lesion degree of liver function. The more serious the liver lesion, the higher the decrease rate of AT-Ⅲ was.

关 键 词：抗凝血酶-Ⅲ 肝炎 失代偿期 肝硬化 

分 类 号：R575.2[医药卫生—消化系统]