老年抑郁症患者血清细胞因子水平的研究  

The study of serum cytokine level in elderly depressed patient

作　　者：郭建雄[1] 陆小兵[1] 杨东英[1] 童梓顺[1] 刘学军[1] 

机构地区：[1]广州市精神病医院,510370

出　　处：《广州医药》2010年第4期8-9,共2页Guangzhou Medical Journal

摘　　要：目的检测老年抑郁症患者与健康人群血清细胞因子IL-6、TNF-α水平,探讨细胞因子在抑郁发病中的作用。方法采用酶联免疫吸附法(ELISA)检测30例首发老年抑郁症患者(抑郁症组)和30例健康老年人(对照组)的血清IL-6、TNF-α的水平并比较,并结合汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)总分及各因子分进行相关分析。结果抑郁症组血清IL-6、TNF-α水平显著高于正常对照组(P<0.05)。IL-6、TNF-α与HAMD、HAMA量表总分呈显著正相关(P<0.05)。结论血清IL-6、TNF-α水平升高可能是老年抑郁症的免疫学标志之一。Objective To explore level of serum cytokine in elderly depressed patient and the association between level of serum cytokine and state of illness. Methods The serum cytokine level was measured by enzymatic-linked immunosorbent assay（ELISA） in case-control study including 30 first-episode elderly depressed patients and 30 healthy controls,and the association between the serum cytokine level and HAMD total score,HAMA total score or the factor score was explored. Results There is significant higher in the level of serum IL-6,TNF-α in elderly patients with depression than those in control（P0.05）.The significant association is found between the level of serum IL-6,TNF-αand HAMD total score,HAMA total score or the factor score（P0.05）.Conclusion The increases in the level of serum IL-6、TNF-αmay be immunological markers of depression in late life.

关 键 词：老年抑郁症患者 细胞因子 

分 类 号：R749.4[医药卫生—神经病学与精神病学]