辛伐他汀对大鼠EAE的防治作用的观察  

Amelioration of Experimental Autoimmune Encephalomyelitis in Rats by Simvastatin

作　　者：段圣杰[1] 谭利明[2] 李昆屯[1] 丁明钊[1] 琚小红[1] 刘晗睿[1] 

机构地区：[1]长治医学院附属和济医院神经内科,046000 [2]中南大学湘雅二医院

出　　处：《长治医学院学报》2010年第3期171-174,共4页Journal of Changzhi Medical College

摘　　要：目的:本研究旨在建立多发性硬化(multiple sclerosis,MS)的理想动物模型-实验性自身免疫性脑脊髓炎(experimental autoimmune encephalomyelitis,EAE),观察比较不同剂量的辛伐他汀对EAE的防治作用。方法:建立Wistar大鼠EAE模型,并用两种不同剂量的辛伐他汀进行干预。观察各组大鼠发病、体重变化情况并进行神经功能评分。取大鼠脑和脊髓组织切片进行检测:用苏木素-伊红染色后在光镜下进行炎性病灶计数。结果:大剂量辛伐他汀可使大鼠EAE发病的潜伏期延长,发病率、神经功能评分和体重损失降低,减少炎性病灶数。结论:大剂量辛伐他汀对大鼠EAE可能具有防治作用。Objective：In our study,we administrate different dose simvastatin to the rats of experimental autoimmune encephalomyelitis （EAE）-an animal model of MS,in order to investigate the therapeutic potential.Methods：The animal model was established in female Wistar rats.Rats were fed with different dose simvastatin.The severity of EAE was scored on a scale 0-5 according to the signs and symptoms.Histological examinations were performed on the sections of brain and spinal cord with the aid of hematoxylin-eosin staining.The number of inflammation in the central nervous system （CNS） was counted under the optical microscope.Results：Comparing to EAE group and the low dose simvastatin group,the EAE of high dose simvastatin group’s rats have prolonged eclipse period,degraded morbility,weight loss and neurological deficit scores,and decreased CNS inflammation focus.Conclusion：High dose Simvastatin have amelioration effect on EAE rats.

关 键 词：辛伐他汀 实验性自身免疫性脑脊髓炎 多发性硬化 

分 类 号：R363[医药卫生—病理学]