Ⅳ期胃癌无进展生存期分析  

Progression-free survival analysis in patients with stage Ⅳ gastric carcinoma

作　　者：张百红[1] 王湘辉[1] 杨文元[1] 

机构地区：[1]兰州军区兰州总医院肿瘤科,兰州730050

出　　处：《山西医科大学学报》2010年第7期591-593,共3页Journal of Shanxi Medical University

摘　　要：目的分析Ⅳ期胃癌无进展生存期(progression-free survival,PFS)及其影响因素。方法回顾分析2005-01～2009-12病理证实的51例Ⅳ期胃癌临床资料。主要终点指标是PFS。结果 51例患者的中位PFS2.0月(95%CI1.650-2.350)。多因素分析发现身体状况评分(ECOG评分)(HR为2.082;95%CI1.359-3.189)和姑息性化疗(HR为4.824;95%CI1.866-12.471)是影响PFS的独立因素。结论身体状况影响晚期胃癌的进展,姑息性化疗或许对晚期胃癌有益。Objective To investigate the progression-free survival（ PFS） of advanced gastric carcinoma patients and its prognostic factors. Methods The clinical data of patients histologically diagnosed as advanced gastric carcinoma were analyzed retrospectively and no prior therapy was eligible. The primary endpoint was PFS. Results The median PFS was 2. 0 months[95% confidence interval （ CI） ,1. 650-2. 350]. The multivariate analysis showed that performance status[hazard ratio（ HR） =2. 082; 95%CI 1. 359-3. 189] and palliative chemotherapy（ HR = 4. 824; 95% CI 1. 866-12. 471） were the independent prognostic factors for PFS. Conclusion Performance status can be used to aid the clinical decision-making. Palliative chemotherapy can be active against advanced gastric carcinoma.

关 键 词：晚期胃癌 无进展生存期 预后因素 多因素分析 

分 类 号：R735.2[医药卫生—肿瘤]