鼻咽癌颅底骨破坏的CT特征及与p53蛋白的关系  

Relationship between the p53 protein expression and CT features of the skull base destruction in nasopharyngeal carcinoma

作　　者：吴梅[1] 江新青[1] 莫蕾[1] 吴红珍[1] 徐宏刚[1] 蒋超[1] 

机构地区：[1]广州医学院附属广州市第一人民医院放射科,广州510180

出　　处：《放射学实践》2010年第7期746-749,共4页Radiologic Practice

摘　　要：目的:探讨鼻咽癌颅底骨质破坏的CT特征及与p53蛋白表达的关系。方法:经病理证实的鼻咽癌患者150例,其中颅底骨质破坏48例。12例患者行鼻咽横轴面CT扫描,其中30例同时行冠状面CT扫描。30例行薄层CT扫描及多平面重组。应用免疫组化SABC法检测所有病例中p53蛋白的表达。结果:颅底骨质破坏分3种:溶骨、成骨和混合性破坏,溶骨性破坏最多见(n=27),破坏部位最多见于斜坡。鼻咽癌及鼻咽炎症中p53蛋白表达率的差异有极显著性意义(P<0.001),p53蛋白表达与鼻咽癌分化程度、颅底骨质破坏相关(P<0.001),溶骨破坏与成骨改变p53阳性表达率有显著差异(P<0.05)。结论:p53蛋白表达与鼻咽癌分化程度、颅底侵犯有一定相关性。CT显示颅底骨质破坏形式可以反映p53蛋白的表达情况。Objective：To study the relationship between the expression of p53 protein and CT features of the skull base involvement in nasopharyngeal carcinoma.Methods：There were 150 patients（skull base destruction 48 cases）of nasopharyngeal carcinoma,all of them were confirmed by biopsy.Transverse CT scan in all cases,coronal CT scan or thin slice spiral CT and multiplanar reconstruction in some cases were performed.And all cases were examined for expression of p53 protein by SABC immunohistochemical method.Results：Bone lesions of the cranial base were classified into three types：lytic,sclerotic and mixed.Osteolytic lesions（n=27）were most common where the clivus was often involved as well.The positive expression for p53 in nasopharyngeal carcinoma and nasopharyngeal inflammation had significant difference（P〈0.001）.p53 protein expression was correlated with histodifferentiation and skull base destruction（P〈0.001）.The positive expression for p53 in osteolytic lesions and sclerotic lesions had significant difference（P〈0.05）.Conclusion：P53 protein expression was correlated with histodifferentiation and skull base destruction.The types of skull base destruction on CT can reflect the expression status of p53 protein.

关 键 词：鼻咽肿瘤 颅骨 体层摄影术 X线计算机 免疫组织化学 

分 类 号：R739.63[医药卫生—肿瘤]