CYP1A1基因多态性与女性子宫内膜癌易感性关系的Meta分析  

Relationship between polymorphism of CYP1A1 gene and endometrial cancer among females:a Meta-analysis

作　　者：张小围[1] 刘贵鹏[1] 

机构地区：[1]中国医科大学附属盛京医院第一微创妇科,沈阳110162

出　　处：《中国生育健康杂志》2010年第3期134-137,共4页Chinese Journal of Reproductive Health

摘　　要：目的综合评价CYP1A1基因多态性与女性子宫内膜癌遗传易感性的关联度。方法通过检索万方、CNKI、维普和PUBMED数据库,获取CYP1A1基因多态性与女性子宫内膜癌易感性关系的病例-对照研究。以子宫内膜癌组与对照组人群基因型分布的OR值为效应指标,采用REVMAN4.2软件进行Meta分析,并根据一致性检验的结果选用合适的模型进行数据的合并。结果入选文献共4篇,其中英文文献1篇,中文文献3篇,累计病例数和对照数分别为908和1 585例。CYP1A1 CC(纯合子模型)合并后OR值为1.19(95%CI:0.81～1.74)。CYP1A1 CT(杂合子模型)合并后OR值为1.37(95%CI:1.12～1.67),CYP1A1等位基因C合并后OR值为1.19(95%CI:1.03～1.39)。结论CPY1A1的基因多态性与子宫内膜癌的易感性有关。Objective To evaluate the relationship between CYP1A1 gene polymorphism and the risk of endometrial cancer among females. Methods A Mcta-analysis was performed using published reports with a case-control design. Results Four ease-control studies consisting of 908 endometrial cancer eases and 1 585 controls were included. Pooled odds ratio （OR） of CYPIA1 CC and CYPIA1 CT was computed with CYPIA1 TT as the reference group. Women carrying a CC genotype had an OR of 1.19 （95 % CI：0. 81-1.74）, and women carrying a CT genotype had an OR of 1.37 （ 95 % Cl： 1.12 0-1.67 ） compared with the TT genotype. The pooled OR of allele C vs T was I. 19 （95 % CI： I. 03-1.39 ）. Conclusion CYPIA1 gene polymorphism is associated with the susceptibility of endometrial cancer.

关 键 词：CYP1A1 基因多态性 子宫内膜癌 META分析 

分 类 号：R737.33[医药卫生—肿瘤]