饮酒及酒精代谢酶基因多态与食管癌发病风险  

Relationship of ADH2,ALDH2 Genotypes and Alcohol Drinking with Risk of Esophageal Cancer

作　　者：丁建华[1] 李苏平[1] 曹海霞[1] 吴建中[1] 高长明[1] 刘燕婷[1] 周建农[1] 常军[2] 姚根红[2] 周余春 

机构地区：[1]江苏省肿瘤防治研究所流行病室,江苏南京210009 [2]泰兴市疾病预防控制中心,江苏泰兴225400

出　　处：《中国肿瘤》2010年第7期453-457,共5页China Cancer

基　　金：2005年江苏省卫生厅医学科技发展基金资助(H200526)

摘　　要：[目的]研究饮酒及乙醇脱氢酶2(ADH2)和乙醛脱氢酶2(ALDH2)基因多态性与食管癌发病风险关系。[方法]对江苏省泰兴市221食管癌新发病例和191对照调查饮酒习惯等因素,采用聚合酶链反应(PCR)和变性高效液相色谱法(DHPLC)检测研究对象ADH2和ALDH2基因型。[结果]①携带ALDH2 G/A或A/A饮酒者患食管癌危险性,分别是携带ALDH2G/G饮酒者或不饮酒者的3.08倍和3.05倍(OR=3.08,95%CI:1.65～5.78;OR=3.05,95%CI:1.49～6.25)。②携带ALDH2 G/A或A/A且酒精消耗总量≥2.5kg·年者患食管癌风险是携带ALDH2G/G且酒精消耗总量<2.5kg·年者12.31倍(OR=12.31,95%CI:3.01～50.37)。③携带ALDH2 G/A或A/A者患食管癌风险,随酒精消耗总量增加呈趋势性显著上升(P=0.023),当达到≥2.5kg·年时患食管癌风险是不饮酒者的6.58倍。④同时携带ALDH2 G/A或A/A和ADH2 G/A或G/G且酒精消耗总量≥2.5kg·年者患食管癌风险,是同时携带ALDH2G/G和ADH2A/A且酒精消耗总量<2.5kg·年者(OR=35.59,95%CI:1.86～680.1)。[结论]可将酒精消耗总量达≥2.5kg·年作为显著增加携带ALDH2 G/A或A/A饮酒者患食道癌风险的阈值。对同时携带ALDH2 G/A或A/A和ADH2 G/A或G/G且酒精消耗总量≥2.5kg·年者,劝其戒酒和定期随访对降低食管癌危害十分有益。[Purpose] To investigate the relationship of alcohol dehydrogenase-2（ADH2） and aldehyde dehydrogenase-2（ALDH2） genotypes as well as alcohol drinking with the risk of esophageal cancer.[Methods] Two hundred and twenty-one esophageal cancer patients and 191 healthy controls from Taixing city of Jiangsu province were enrolled in this study.ADH2 and ALDH2 genotypes were examined by PCR and denaturing high-performance liquid chromatography（DHPLC）.[Results] ①Alcohol drinkers with ALDH2 G/A or A/A genotype showed a significantly increased risk of esophageal cancer compared to alcohol drinkers with ALDH2 G/G genotype（OR=3.08,95%CI：1.65～5.78） or non-alcohol drinkers（OR=3.05,95CI：1.49～6.25）.②Compared to alcohol drinkers with ALDH2 G/G genotypes and cumulative amount of alcohol consumption 2.5（kg·years）,alcohol drinkers with ALDH2 G/A or A/A genotypes and cumulative amount of alcohol consumption ≥2.5（kg·years） were at a significantly higher risk of esophageal cancer（OR=12.31,95%CI：3.01～50.37）.③A dose-dependent positive result was found between cumulative amount of alcohol consumption and the risk of esophageal cancer in individuals carrying ALDH2 G/A or A/A（P=0.023）.Among ALDH2 G/A or A/A carriers,the risk of esophageal cancer was 6.58-fold higher in drinkers with cumulative amount of alcohol consumption≥2.5（kg·years） than that in non-alcohol drinkers.④Compared with drinkers carrying both ALDH2 G/G and ADH2 A/A and cumulative amount of alcohol consumption 2.5（kg· years）,drinkers carrying both ALDH2 G/A or A/A and ADH2 G/A or G/G and cumulative amount of alcohol consumption ≥2.5（kg·years） showed a significantly increasing risk of esophageal cancer（OR=35.59,95%CI：1.86～680.1）.[Conclusion] The cumulative amount of alcohol consumption ≥2.5（kg·years） may be considered as a threshold of significant increase risk in both ALDH2 G/A or A/A and ADH2 G/A or G/G carriers suffering from esophageal cancer.This result suggests that to help lower t

关 键 词：食管癌 饮酒 乙醇脱氢酶2(ADH2) 乙醛脱氢酶2(ALDH2) 病例对照研究 

分 类 号：R730.1[医药卫生—肿瘤] R735.1[医药卫生—临床医学]