血管内皮生长因子在非小细胞肺癌中的表达及其意义  

Vascular endothelial growth factor in non small cell lung carcinoma expression and its significance

作　　者：杨国利[1] 张力建[1] 谢玉泉[1] 

机构地区：[1]北京医科大学临床肿瘤学院

出　　处：《中华医学杂志》1999年第2期104-105,共2页National Medical Journal of China

摘　　要：目的探讨血管内皮生长因子（ＶＥＧＦ）在肺癌中的表达及与肿瘤生长转移、预后和新生血管形成的关系。方法对５３例周围型非小细胞肺癌患者，采用免疫组织化学法，进行ＶＥＧＦ抗体标记和肿瘤组织ＶＥＧＦ表达；用Ｆ８因子抗体标记瘤组织的血管生成。结果５３例根治手术的周围型非小细胞肺癌ＶＥＧＦ高表达和低表达的微血管密度间差异有显著性意义，（Ｐ＜０００１）。高表达ＶＥＧＦ，有淋巴结转移的占７６％（２９／３８）；无淋巴结转移的占２６％（４／１５）（Ｐ＜０００１）。ＣＯＸ分析表明，ＶＥＧＦ可作为独立的判断预后指标。结论ＶＥＧＦ的表达与肿瘤的血管生成、生长和淋巴结转移密切相关；高表达预后更差；Objective To clarify the relationship between the expression of vascular endothelial growth factor (VEGF) and the angiogenesis, invasion, prognostic value in non-small cell lung cancer. Methods Immunohistochemistry. Results 53 patients with NSCLC after radical resection were evaluated . A significantly higher microvessel density (MVD) was observed in the tumors with high expression of VEGF compared with that of the low expression ( P <0.001). 29 patients (80%,29/33) with the high expression of VEGF showed lymphonode metastasis and 4 patients (27%,4/15) unlymphonode metastasis ( P <0 001). By Cox ’s proportional hazard model analysis, the expression of VEGF was considered an independent predictor for the prognosis of NSCLC. Conclusions The expression of VEGF has a significant correlation among MVD, growth, invasion, and lymphonode metastasis. The patient with the tumor of the higher expression of VEGF and MVD may have poor prognosis. VEGF may be an independent predictor of prognosis.

关 键 词：肺肿瘤 非小细胞肺癌 血管内皮 生长因子 VEGF 

分 类 号：R734.202[医药卫生—肿瘤]