胃癌发生中的独特肿瘤标记物—LI-cadherin  

The unique tumor marker of gastric carcinoma:LI-cadherin

作　　者：郑正[1] 牛建华[2] 

机构地区：[1]新疆石河子大学医学院,新疆石河子83200 [2]新疆石河子大学第一附属医院,新疆石河子832008

出　　处：《现代生物医学进展》2010年第12期2391-2393,2400,共4页Progress in Modern Biomedicine

摘　　要：LI-cadherin,也被称为cadherin-17,是肠上皮细胞中一种贯穿细胞膜的、钙依赖性的、介导细胞间连接的糖蛋白。与经典钙黏蛋白相比,LI-cadherin是一种具备独特结构和功能的新型钙黏蛋白。LI-cadherin由7个胞外重复序列和一个只包含20个氨基酸残基的较短的胞质尾区组成。在人体中,LI-cadherin特异性的位于肝细胞和肠细胞中的底外侧区。而LI-cadherin介导细胞连接时,既不与链蛋白结合,也不导致β-catenin的上调。一些研究发现,在胃癌中LI-cadherin的过度表达与CDX-2显著相关,而且在肠化生中CDX-2的表达总是与LI-cadherin呈现很强的成对性。最新的研究认为LI-cadherin的表达与胃癌的发生、发展、转移及预后均有关系。在针对胃癌的临床处理方面,LI-cadherin将会是有用的肿瘤标记物。LI-cadherin,also called cadherin-17,is a calcium-dependent transmembrane glycoprotein that mediates cell-cell adhesion in intestinal epithelium.Compared with classical cadherins,LI-cadherin represents a novel type of cadherin with a distinct structure and function.LI-cadherin consists of seven extracellular cadherin repeats and a rather short cytoplasmic domain comprising only about 20 amino acids.In human,LI-cadherin is localized to the basolateral domain of hepatocytes and enterocytes.When mediating cell-cell adhersion,LI-caherin was neither associated with catenins nor did it induce an upregulation of β-catenin.Some studied indicate that overexpression of LI-cadherin is significantly associated with CDX-2 in gastric cancer.Furthermore,the expression of CDX-2 and LI-cadherin proteins was strongly coupled in intestinal metaplasia.Some recent studies indicate that the expression of Li-cadherin should be related to the origins of varied tumors,development,metastasis and prognosis in stomach.LI-cadherin has been regarded as an useful biological marker for practical management of patients with gastric cancer.

关 键 词：肝肠钙黏蛋白 胃癌 肿瘤标记物 

分 类 号：R735.2[医药卫生—肿瘤]