间隙连接蛋白在肾脏的病理生理作用  

Physiopathological action of connexin in kidney

作　　者：王彬(综述)[1] 甘卫华(审校)[1] 

机构地区：[1]南京医科大学第二附属医院儿科,210003

出　　处：《国际儿科学杂志》2010年第4期390-392,共3页International Journal of Pediatrics

摘　　要：间隙连接蛋白是机体固有的与细胞生长发育及增殖、分化等密切相关的膜表面分子,在肾脏组织中有丰富表达,与肾脏疾病密切相关.该文就间隙连接蛋白分子的特点,在肾脏组织的表达、功能以及影响因素等进行综述.As a kind of inherent membrane surface molecules of our human body,connexins are closely related to the cell growth,proliferation and differentiation,which are highly expressed in kidney.Many kidney diseases have a close relationship with connexins＇ altered expression and disordered function.This paper is dedicated to review the characteristics of connexins molecules,the expression and corresponding functions in the kidney tissues,as well as the possible regulation mechanisms in the kidney tissues in order to explore their applications and value in medical study.

关 键 词：间隙连接蛋白 肾脏脉管系统 肾小球系膜细胞 足细胞 

分 类 号：R735.702[医药卫生—肿瘤]