上海市部分地区乳腺癌组织中ER、PR、HER-2、PCNA、P53的表达及临床意义  

Expression of ER,PR,HER-2,PCNA and P53 genes in breast cancer patients in Shanghai and the relevant clinical significance

作　　者：卫旭彪[1] 韩铖琛[1] 徐晶晶[1] 郑唯强[1] 

机构地区：[1]第二军医大学长海医院病理科,上海200433

出　　处：《第二军医大学学报》2010年第7期748-752,共5页Academic Journal of Second Military Medical University

基　　金：国家自然科学基金(30870975)~~

摘　　要：目的探讨上海部分地区乳腺癌患者组织中ER、PR、HER-2、PCNA、P53的表达情况,并分析其表达与乳腺癌临床病理的关系。方法采用免疫组织化学方法 ,检测本地区544例乳腺癌组织中ER、PR、HER-2、PCNA、P53的表达,并了解各项生物学指标与乳腺癌临床病理之间的关系。结果 544例乳腺癌中,ER、PR、HER-2、PCNA、P53的阳性表达率分别是62.2%、57.2%、15.1%、82.6%、58.5%。ER、PCNA及P53阳性表达与肿瘤大小相关(P<0.05或P<0.01)。HER-2和PCNA的阳性表达与腋淋巴结转移也有相关性(P<0.01)。ER与PR的表达正相关(r=0.452,P=0.000),PR与P53表达正相关(r=0.520,P=0.03)。三阴性乳腺癌共123例,占22.6%,其淋巴结转移比例高于非三阴性乳腺癌(P<0.01)。HER-2与PCNA、HER-2与P53共表达与腋淋巴结转移有相关性(P<0.01)。结论人口老龄化因素对本地区乳腺癌免疫组化指标的表达存在一定影响,联合检测乳腺癌ER、PR、HER-2、PCNA、P53的表达在乳腺癌的诊断、指导治疗及预后判断中可能具有一定的临床意义。Objective To investigate the expression of ER,PR,HER-2,PCNA and P53 in breast cancer patients in Shanghai and the relevant clinical significance.Methods Expressions of ER,PR,HER-2,PCNA and P53 in the breast cancer tissues of 544 patients in Shanghai were detected by immunohistochemistry methods.Statistical analysis was applied to analyze the relationship of these immunohistochemical indices with the clinicopathological features of breast cancer.Results The positive rates of ER,PR,HER-2,PCNA and P53 in the breast cancer tissues of 544 patients were 62.2%,57.2%,15.1%,82.6% and 58.5%,respectively.The expressions of ER,PCNA and P53 were correlated with the tumor size（P0.05,P0.01）.The expressions of HER-2 and PCNA were correlated with axillary lymphatic metastasis（P0.05,P0.01）.ER expression was positively correlated with PR expression（r=0.452,P=0.000）and PR expression was positively correlated with P53 expression（r=0.520,P=0.03）.The 123（22.6%）patients with triple-negative breast cancer（TNBC）had a higher axillary lymphatic positive rate than patients with non-TNBC（P0.01）.Co-expression of HER-2 with PCNA and co-expression of HER-2 with P53 were positively correlated with lymphatic metastasis（P0.05）.Conclusion Population aging has a influence on the immunohistochemical characteristics of breast cancer patients patients in Shanghai.Combined examination of ER,PR,HER-2,PCNA and P53 is of clinical significance in the diagnosis,treatment,and prognosis prediction of breast cancer patients.

关 键 词：上海 乳腺肿瘤 生物学指标 免疫组织化学 

分 类 号：R737.3[医药卫生—肿瘤]