喹乙醇对鸡骨髓细胞染色体畸变和微核率的影响  

Effect of Olaquindox on chromosome aberration and micronuclear rate for bone marrow cells of chicks

作　　者：由天姿[1] 贾琳琳[1] 贺笛[1] 李术[1] 

机构地区：[1]东北农业大学动物医学学院,哈尔滨150030

出　　处：《东北农业大学学报》2010年第7期103-107,共5页Journal of Northeast Agricultural University

基　　金：环保公益性科研专项经费资助项目(200909043)

摘　　要：为了评价喹乙醇对家禽的致突变性,试验将鸡分为试验组(150 mg.kg-1.diet喹乙醇)、阴性对照组(灭菌生理盐水)、阳性对照组(环磷酰胺),连续染毒15 d,间隔5 d采样一次,检测骨髓细胞染色体畸变率和微核率。结果表明,试验组骨髓细胞染色体畸变率和微核率与阴性对照组比较差异显著(P<0.01),且呈时间-效应关系。表明喹乙醇是鸡骨髓细胞突变的诱变剂。The purpose was to determine the mutagenicity of experimental Olaquindox poisoning in poultry. Chicks were divided into experimental group（150 mg.kg-1 .diet Olaquindox）, negative control group （sterile saline） and positive control group（cyclophosphamide）. Three groups of chicken were administered the abovementioned agentia by lavage for 15 days, every five days to do a test. And then chromo-some aberrated rates of bone marrow cells and the micronucleum rates were detected. The results showed that chromosome aberration test and microcleus test in chicks were positive and showed the time-effect relationship. It was concluded that Olaquindox poisoning could induce the injury of bone marrow cells of chicks.

关 键 词：喹乙醇 鸡 骨髓细胞 染色体畸变 微核率 

分 类 号：S858.31[农业科学—临床兽医学]