星形细胞瘤中核因子kB与热休克蛋白的关系  

The Relationship between NF kB and HSP70 in Astrocytoma

作　　者：杨开勇[1,2,3] 毛伯镛[1,2,3] 蔡晓东 张尚福[1,2,3] 陈娘[1,2,3] 

机构地区：[1]华西医科大学附属第一医院神经外科 [2]深圳市红十字医院神经外科 [3]华西医科大学附属第一医院病理科

出　　处：《华西医学》1999年第1期31-32,共2页West China Medical Journal

摘　　要：核因子ｋＢ与热休克蛋白７０均是蛋白质，前者活化后进入细胞核调节相关基因表达，后者是机体在某些应激状态下才合成以维持细胞功能。本文采用免疫组织化学ＳＰ法对４０例星形细胞瘤标本进行分析，分别计算核因子ｋＢ与热休克蛋白７０的核阳性率，并进行相关分析，发现热休克蛋白７０的核阳性率随核因子ｋＢ核阳性率的变化而变化，二者呈正相关关系。Objective:To detect whether there are some relationship between the activity of nuclear factor kappa B(NF-kB)and the expresion of heat shock protein 70(HSP70).Methods:40 formalin fixed astrocytoma specimen were examined by immunohistochemistry SP methods with anti-P65 and anti-HSP70.Results:The positive nuclear staining of NF-kB/P65 ranges from 10% to 80% wile that of HSP70 ranges from 15% to 100%,the correlation coefficient was 0 79.Conclusion:There is some quantitative correlation between NF-kB and HSP70.

关 键 词：核因子KB 热休克蛋白70 星形细胞瘤 

分 类 号：R730.264[医药卫生—肿瘤]