2(3)-叔丁基-4-羟基茴香醚对乙醇诱发大鼠胃粘膜损伤的保护作用  

PROTECTION AND ANTI OXIDATIVE MECHANISM OF 2(3) TERT BUTYL 4 HYDROXYANISOLE AGAINST ETHANOL INDUCED GASTRIC LESION IN RATS

作　　者：王立新[1] 林三仁[1] 

机构地区：[1]北京医科大学消化疾病研究中心

出　　处：《药学学报》1999年第3期168-171,共4页Acta Pharmaceutica Sinica

摘　　要：目的：研究叔丁基４羟基茴香醚（ＢＨＡ）对乙醇诱发胃粘膜损伤的保护作用。方法：通过给大鼠ｉｇ无水乙醇制备胃粘膜损伤模型，测定胃粘膜内一些酶的活性和ＭＤＡ含量。结果：ｉｇＢＨＡ２０和１００ｍｇ·ｋｇ－１·ｄ－１连续３ｄ，能显著防止乙醇诱发的胃粘膜损伤，并降低由乙醇所致的ＭＤＡ含量增加。ＢＨＡ有诱导醌还原酶、谷胱甘肽还原酶活性增加的作用，且能阻止由乙醇引起的醌还原酶、谷胱甘肽还原酶和ＳＯＤ活性的降低。结论：ＢＨＡ对乙醇诱发大鼠胃粘膜损伤有保护作用。AIM: The protection and anti oxidative mechanism of 2(3) tert butyl 4 hydroxyanisole(BHA) against ethanol induced gastric mucosa lesion in rats were evaluated. METHODS: Gastric mucosal lesions were induced by oral administration of absolute ethanol in rats. The activities of some enzymes and MDA content in gastric mucosa were determined. RESULTS: Oral administration of BHA at 100 mg·kg -1 and 20 mg·kg -1 reduced significantly the gastric lesion induced by ethanol, and inhibited the increase of MDA in gastric mucosa. Compared with normal control, BHA was found to increase the activities of quinone reductase (QR) and glutathione reductase (GR). In ethanol treated rats decreases of QR, GR and SOD were observed. However, BHA was shown to prevent the decrease of QR, GR and SOD in gastric mucosa induced by ethanol. CONCLUSION: These results suggest that BHA has protective effect against ethanol induced gastric mucosal lesion via increasing the activities of anti oxidative enzymes and anti lipid peroxidation.

关 键 词：胃溃疡 HBA 胃粘膜损伤 乙醇 大鼠 抗氯化剂 

分 类 号：R573.105[医药卫生—消化系统] R977.9[医药卫生—内科学]