急性脑梗塞患者血清肿瘤坏死因子-α的变化  

Changes and significance of serum tumor necrosis factor-α in acute cerebral infarction patients

作　　者：吴映曼[1] 蔡毅[1] 

机构地区：[1]海南省农垦总医院神经内科,海南海口570312

出　　处：《中国热带医学》2010年第9期1110-1111,共2页China Tropical Medicine

基　　金：海南省2008年自然科学基金资助项目(808221)

摘　　要：目的观察急性脑梗塞患者血清肿瘤坏死因子-α(TNF-α)水平的动态变化,探讨TNF-α在脑梗塞发病机制中的作用及临床意义。方法采用放射免疫分析法连续检测50例急性脑梗塞患者发病第1、3、7和28d血清肿瘤坏死因子-α水平,并与28例短暂性脑缺血发作患者和30例正常对照组进行比较。结果急性脑梗塞患者于发病第1dTNF-α开始升高(P<0.05),第3d达峰值水平(P<0.01),然后逐渐下降,至第28d时仍高于对照组和短暂性脑缺血发作组(P<0.05);梗死体积越大,TNF-α水平越高,与其他各组相比差异有统计学意义(P<0.05或P<0.01)。短暂性脑缺血发作组患者血清TNF-α与正常对照组之间差异无统计学意义(P>0.05)。结论 TNF-α水平的动态变化与急性脑梗塞的发生发展有关,TNF-α水平与梗死灶体积有关,TNF-α参与脑梗塞患者炎症/免疫反应发生发展过程。Aim To investigate the trend of serum tumor necrosisFactor-alpha（TNF-α）level changes in patients with acute ischemic cerebralinfarction,and to assess their effects and clinical significance.Methods Fifty patients with acute cerebral infarction（ACI）,28 patients with transient ischemic attack and 30 normal individuals were studied.Blood samples were collected from patients with acute to the peak on the third day（P 0.01）,and then decreased gradually,but was still higher than that in normal control group and transient ischemic attack group on the twenty-eighth day（P0.05）.As the focal infarction size presented more larger and the serum TNF-α level would be more higher.In comparison with other groups,the differences were significant（P0.05 or P0.01）.The serum TNF-α level was higher in well recovered patients than those without impairmen（tP0.05）.No significant difference was observed on the level of TNF-α between transient ischemic attack group and normal control group（P0.05）.Conclusion This study suggests that the trend of serum TNF-α level changes is correlated with the occurrence and development of acute cerebral infarction,and the TNF-α levels is correlated with the size of the infarct focus.TNF-α plays a role in the occurrence and development of inflammatory/immune process of ACI Patient..

关 键 词：急性脑梗塞 肿瘤坏死因子-Α 炎症免疫 

分 类 号：R743.33[医药卫生—神经病学与精神病学]