A Second Protein Marker of Caveolae:Caveolin-2  

作　　者：Liu-luan Zhu Ying Cui Yong-sheng Chang Fu-de Fang 

机构地区：[1]National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences ＆ Peking Union Medical College, Beijing 100005, China

出　　处：《Chinese Medical Sciences Journal》2010年第2期119-124,共6页中国医学科学杂志（英文版）

基　　金：Supported by National Basic Research Program of China (973 Program) (2004CB518602,2006CB503909);National High Technology Research and Development Program of China (863 Program) (2009AA02Z192)

摘　　要：Caveolin-2,a protein about 20 kD,is a major component of the inner surface of caveolae,small invaginations of the plasma membrane.Similar with caveolin-1 and caveolin-3,it serves as a protein marker of caveolae.Caveolin-1 and-2 are located next to each other at 7q31.1 on human chromosome,the proteins encoded are co-localized and form a stable hetero-oligomeric complex,distributing similarly in tissue and cultured cells.Caveolin-3 is located on different chromosomes but confirmed to interact with caveolin-2.Caveolin-2 is similar to caveolin-1 in many respects but differs from the latter in functional domains,especially in G-protein binding domain and caveolin scaffolding domain.The mRNAs of both caveolin-1 and caveolin-2 are most abundantly expressed in white adipose tissue and are induced during differentiation of 3T3-L1 cells to adipocytes.Caveolin-2-deficinet mice demonstrate clear pulmonary defects,with little or no change in caveolin-1 expression and caveolae formation,suggesting that caveolin-2 plays a selective role in lung functions.Caveolin-2 is also involved in lipid metabolism and human cancers.

关 键 词：caveolin-2 LUNG lipid metabolism CANCER 

分 类 号：Q51[生物学—生物化学] Q987