白细胞介素-6-634 C/G基因多态性与脑梗死的关系  

The relationship of IL-6-634C/G gene polymorphism with cerebral infarction

作　　者：谷文萍[1] 唐春柳[1] 龚姣娥[1] 梁静[1] 董荣峥[1] 丁远英[1] 杨期东[1] 

机构地区：[1]中南大学湘雅医院神经内科,湖南长沙410008

出　　处：《中风与神经疾病杂志》2010年第5期416-419,共4页Journal of Apoplexy and Nervous Diseases

摘　　要：目的探讨中国湖南汉族人群IL-6-634C/G基因多态性与脑梗死的关系。方法应用聚合酶链反应-限制性酶切片段长度多态性分析(PCR-RFLP)方法对中国湖南汉族314例脑梗死患者和326例与之年龄、性别等相匹配的健康体检者进行IL-6-634C/G基因多态分析,并经基因测序证实。结果在中国湖南汉族人群中,IL-6-634C/G存在GG、CG、CC3种基因型;3种基因型和等位基因频率在脑梗死组和对照组之间比较差异无显著性(P>0.05)。结论 IL-6-634C/G基因多态性可能不是湖南汉族人群脑梗死的遗传易感基因。Objective To investigate the relationship of IL-6-634C/G gene polymorphism and cerebral infarction （CI） in Hunan Hans.Methods IL-6-634C/G polymorphism was detected by PCR-RFLP and DNA sequencing in 314 CI patients and 326 healthy controls.Results IL-6-634C/G have GG,CG and CC genotypes in Hunan Hans.There was no significant differences of genotypes and alleles frequencies between the controls and CI group （P〉0.05）.Conclusion The Chinese Hunan Han Nationality crowd has the IL-6-634C/G gene polymorphism.There was no relationship between the IL-6-634C/G gene polymorphism and CI in Hunan Hans.

关 键 词：IL-6-634C/G 脑梗死 基因多态性 

分 类 号：R743.3[医药卫生—神经病学与精神病学]