谷胱甘肽S转移酶M1基因型与老年性白内障易感性关系探讨  

Relationship between GSTM1 genotype and susceptibility to senile cataract

作　　者：郝燕霞[1] 何守志[1] 谷志远[1] 赵亚力[1] 李星星[1] 王常观[1] 李琪[1] 刘铁成[1] 

机构地区：[1]中国人民解放军总医院眼科

出　　处：《中华眼科杂志》1999年第2期104-106,共3页Chinese Journal of Ophthalmology

基　　金：中华眼科学会麦格科研基金

摘　　要：目的探讨谷胱甘肽Ｓ转移酶（ｇｌｕｔａｔｈｉｏｎｅＳｔｒａｎｓｆｅｒａｓｅ，ＧＳＴ）基因缺失与老年性白内障形成的关系。方法应用多聚酶链式反应（ｐｏｌｙｍｅｒａｓｅｃｈａｉｎｒｅａｃｔｉｏｎ，ＰＣＲ）方法对７７例老年性白内障患者及７６例健康对照者外周血细胞进行ＧＳＴＭ１基因检测，并对其中的２２例老年性白内障晶体上皮细胞进行ＧＳＴＭ１基因检测。结果白内障组ＧＳＴＭ１基因缺乏率为５３．２５％，对照组为４６．０５％，两组间差异无显著性（χ２＝０．７５０，Ｐ＞０．０５，ＯＲ＝０．７５）。２０例老年性白内障晶体上皮细胞内ＧＳＴＭ１基因检测与外周血细胞检测结果一致（Ｐ＜０．０１）。结论ＧＳＴＭ１基因缺失与老年性白内障的发生缺乏显著关系。Objective To study the relationship between the glutathione s transferase gene deletion and cataract formation. Methods Blood cells of total of 77 cases with senile cataract and 76 controls were detected for GSTM1 gene, and the subcapsular epithelial cells of 22 cataract lenses were also detected for GSTM1 gene. Results The GSTM1 gene deletion rate in cataract group was 53.25% and that in the control group was 46.05%, they being not significantly different statistically (χ 2=0.750, P >0.05, OR =0.75). GSTM1 gene deletion rate in the subcapsular epithelial cells of 20 cases was basically consistent with that in blood cells. Conclusion GSTM1 gene deletion is not related to senile cataract formation.

关 键 词：谷胱甘肽转移酶 白内障 易感性 M1基因 

分 类 号：R776.102[医药卫生—眼科]