3,4,5-三甲氧基苯胺的合成  

Synthesis of 3,4,5-Trimethoxyaniline

作　　者：罗成[1] 曹威[1] 龚小伦[1] 郭文勇[1] 沈玉芳[1] 

机构地区：[1]湖北省化学研究院,湖北武汉430074

出　　处：《化学与生物工程》2010年第7期51-53,共3页Chemistry & Bioengineering

摘　　要：以没食子酸为起始原料,经甲基化、硝基化以及还原等步骤合成了3,4,5-三甲氧基苯胺,并对3,4,5-三甲氧基硝基苯还原为3,4,5-三甲氧基苯胺的合成条件进行了优化。用IR和1HNMR对各中间产物进行了表征。该路线反应收率明显提高,反应时间大幅缩短,为实现工业化生产提供了可能。In this paper,3,4,5-trimethoxyaniline was synthesized with gallic acid as starting material by methylation,nitration,reduction.The structures of the intermediates were characterized by IR and ^1HNMR.Meanwhile,the synthetic conditions of 3,4,5-trimethoxyaniline by reduction of 3,4,5-trimethoxynitrobenzene were optimized to greatly increase the yield and shorten the reaction time.It permits the technology to be applied to industrial prouction.

关 键 词：没食子酸 3 4 5-三甲氧基苯甲酸 3 4 5-三甲氧基硝基苯 3 4 5-三甲氧基苯胺 合成 

分 类 号：O625.631[理学—有机化学]