镓合金的细胞毒性评价  

Evaluation on Cytotoxicity of Gallium Alloy

作　　者：闻学雷[1] 张彩霞[1] 陈之军 孟爱英[1] 

机构地区：[1]上海第二医科大学附属第九人民医院上海生物材料研究测试中心,上海200023

出　　处：《生物医学工程学杂志》1999年第1期19-20,共2页Journal of Biomedical Engineering

基　　金：上海市高等学校科技基金

摘　　要：细胞毒性是评价生物材料生物相容性优劣的一个重要指标。对新研制的镓合金用Ｌ９２９ 小鼠成纤维细胞，采用改进的体外细胞相对增殖度法，对其细胞毒性进行了评价。用紫外分光光度仪测定光吸收度，镓合金溶液的细胞相对增殖率为镓合金溶液光吸收度与阴性对照溶液光吸收度的比值，将材料溶液的细胞相对增殖率转换成细胞毒性级来评价材料。结果表明，镓合金的细胞毒性评分为０ 级，无细胞毒性。Cytotoxicity is an important indicator to the biocompatibility of biomaterials. In this study, the cytotoxicity of Gallium alloy was evaluated by the method of cell relative growth rate in vitrousing L 929 mouse fibroblast. The cell relative growth rate of Gallium alloy was the absorbency ratio between the solution of Gallium alloy and negative control. The relative growth rates of Gallium aloy were converted into the scores of cytotoxicity. It was found from the results that Gallium alloy had no cytotoxicity.

关 键 词：镓合金 细胞毒性 牙科材料 生物相容性 

分 类 号：R783.1[医药卫生—口腔医学]