异佛司可林滴眼对清醒兔的降眼压作用  

Suppressing effects of isoforskolin administered topically on intraocularpressure in conscious rabbits

作　　者：聂玲辉[1,2] 李新华[1,2] 陈植和[1,2] 王新华[1,2] 王德成[1,2] 

机构地区：[1]昆明医学院第二附属医院眼科 [2]昆明医学院云南省天然药物药理重点实验室

出　　处：《眼科研究》1999年第2期90-92,共3页Chinese Ophthalmic Research

基　　金：卫生部眼科实验室科学基金;云南省自然科学基金

摘　　要：目的研究异佛司可林（ｉｓｏＦ）悬液滴眼对清醒兔眼内压（ＩＯＰ）的作用。方法以气动式非接触眼压计测ＩＯＰ，并记录药物的表面刺激反应。结果０．２５％和１％ｉｓｏＦ分别降低正常ＩＯＰ达０．３７和０．４３ｋＰａ。对水负荷高眼压（ＯＨＴ），ｉｓｏＦ从０．０６％到１％呈浓度依赖性的抑制ＩＯＰ升高；０．２５％ｉｓｏＦ作用最强，使给药侧ＩＯＰ较对照侧低０．９５ｋＰａ。实验还显示，０．２５％ｉｓｏＦ基本无刺激，而１％时有轻度刺激反应。结论在清醒兔无眼创伤下测ＩＯＰ，ｉｓｏＦ对正常ＩＯＰ和水负荷诱导的ＯＨＴ均有抑制作用；０．２５％ｉｓｏＦ悬液基本无刺激性，而１％浓度时有轻度刺激反应。ObjectiveTo study the effects of isoforskolin (isoF) suspention administered topically on the intraocular pressure (IOP) in conscious rabbits.MethodsIOP was measured with pneumatonometer,and the irritation responses were also recorded.Results0.25% and 1% isoF lowered normal IOP by 0.37 and 0.44 kPa respectively.In water loading induced ocular hypertension (OHT),isoF from 0.06% to 1% concentration dependently suppressed the increase in IOP,and the maximal effect was obtained by 0.25% isoF which suppressed IOP by 0.95 kPa compared with the contralateral control IOP.Simultaneously,0.25% isoF showed little while 1% isoF showed weak topical irritating responses.ConclusionBy measuring IOP without eye invasion,isoF showed ocular hypotensive effect on both normal IOP and water induced OHT in conscious rabbits;additionally,isoF suspension at 0.25% exerted little while at 1% exerted weak topical irritating actions.

关 键 词：异佛司可林 眼内压 青光眼 兔 降眼压 

分 类 号：R775.05[医药卫生—眼科] R988.1[医药卫生—临床医学]