氟-肝素表面修饰人工晶状体的制备及物理光学性能的研究  

Preparation of F heparin surface modified intraocular lens and study onits physical and optical properties

作　　者：郭红玉[1,2] 袁佳琴[1,2] 孙慧敏[1,2] 顾汉卿[1,2] 陆茉珠[1,2] 

机构地区：[1]天津医科大学世界人工晶体中国天津培训中心 [2]天津市泌尿外科研究所

出　　处：《眼科研究》1999年第2期95-97,共3页Chinese Ophthalmic Research

摘　　要：目的以氟－肝素对聚甲基丙烯酸甲酯（ＰＭＭＡ）人工晶状体进行表面修饰，并测定其物理光学性能。方法利用载能离子束联合低温等离子体技术对ＰＭＭＡ人工晶状体进行氟－肝素表面修饰，通过物理光学方法对不同剂量表面修饰的人工晶状体进行透光率、分辨率、屈光度及袢的抗拉强度的测定。结果氟－肝素修饰人工晶状体氟离子剂量为２×１０１４～５×１０１４ｉｏｎｓ／ｃｍ２，其机械、光学性能和未修饰人工晶状体比较无明显区别，在短波光线及紫外线区（３６０～４９０ｎｍ）修饰人工晶状体的透光率明显低于未修饰人工晶状体。结论氟－肝素修饰人工晶状体有效地阻挡了短波光线及紫外线，起到保护视网膜的作用。ObjectiveTo prepare the surface modified IOL with F ions and heparin and to study the physical and optical properties.MethodsUsing the technique of carrier energy ion beam combined low temperature and low pressure plasma to modify the surface of PMMA IOL with F ions and heparin.The transmittance,resolution,diopter and anti compression intensity of loops were determined by using physical and optical methods.ResultsThe surface modified IOLs with F ions 2×10 14 ～5×10 14 ions/cm 2 and heparin showed no difference from the control PMMA IOLs in their mechanical and optical properties.However,the transmittance of the surface modified IOLs in the short wave light zone and ultraviolet rays(360～490nm) was obviously lower than the unmodified IOLs.ConclusionF-heparin modified IOL can decrease the harmful effect of the short wave light and ultravoilet rays to the retina.

关 键 词：人工晶状体 表面修饰 白内障 人工晶体植入术 

分 类 号：R776.1[医药卫生—眼科] R318.18[医药卫生—临床医学]