黄斑玻璃疣特征预见老年黄斑变性的发生  

The macular drusen characteristics may predict the development ofage related macular degeneration

作　　者：陈松[1,2] 聂爱光[1,2] 谭家铨[1,2] 姜德咏[1,2] 唐朝珍[1,2] 

机构地区：[1]湖南医科大学第二附属医院眼科 [2]天津市眼科医院

出　　处：《眼科研究》1999年第2期125-128,共4页Chinese Ophthalmic Research

摘　　要：目的探讨黄斑玻璃疣与老年黄斑变性（ＡＭＤ）发病的危险性。方法于１９８９年始观察了早期ＡＭＤ患者５４例（５４眼）。结果平均追踪５５个月，追踪期内玻璃疣数量及融合程度有不同程度增加，１８例（３３．３３％）患者发生了ＡＭＤ，黄斑玻璃疣发生渗出性ＡＭＤ的５年累积危险性为３７．７８％，其中视网膜下新生血管膜（ＳＲＮＶＭＳ）４眼（７．４％），视网膜色素上皮（ＲＰＥ）脱离４眼（７．４％），地图状萎缩１０眼（１８．５１％）。具有融合的软性玻璃疣的相对危险度是３．１４倍，数量较多（＞Ⅱ级）的相对危险度是６．８９倍，玻璃疣位于中心凹区的相对危险度是２．６倍。结论揭示具有高危险特征的黄斑玻璃疣具有发生ＡＭＤ的危险性。ObjectiveTo investigate the development of age related macular degeneration(AMD) with macular drusen characteristics.Methods54 cases (54 eyes) of suspected AMD with macular drusen were followed up from 1989.ResultsDuring the follow up period,the number and confluence degree of drusen had increased,18 patients had AMD over an average follow up of 55 months (37.78%, cumulative risk in five years),4 eyes had a new vessel membrane,4 eyes had retinal pigment epithelial(RPE) detachments,and 10 eyes had geographic atrophy.The features of the drusen were analyzed,including association with drusen confluence (Relative risk=3.14, P <0.005),drusen numbers above two degree(Relative risk=6.89, P <0.005)and drusen distribution in central fovea (Relative risk=2.6, P <0.01).ConclusionThe presence of high risk drusen characteristics may be predicted the development of advanced AMD.

关 键 词：黄斑变性 黄斑玻璃疣 预见 老年人 

分 类 号：R774.5[医药卫生—眼科]