颈胸腹三切口手术治疗中上段食管癌临床疗效分析  

Clinical study of effects of cervicothoracic-abdominal three-incision operation in patients with middle-upper esophageal cancer

作　　者：陈宏[1] 曾钊慧 赵仁贵[2] 

机构地区：[1]重庆市涪陵区中医院,408000 [2]重庆涪陵中心医院,408000

出　　处：《检验医学与临床》2010年第14期1414-1415,1418,共3页Laboratory Medicine and Clinic

摘　　要：目的通过观察三切口手术对中上段食管癌患者血管内皮生长因子(VEGF)和炎性反应因子的影响,探讨其临床疗效。方法将244例中上段食管癌患者分为实验组(124例)和对照组(120例),记录术后并发症和术后生存率,测定血清超敏C反应蛋白(hs-CRP)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)和VEGF等指标。结果较之术前和同期对照组,实验组术后近期并发症发生率差异无统计学意义(P>0.05);但实验组术后近期血清hs-CRP、IL-6、TNF-α和VEGF水平显著下降,差异有统计学意义(P<0.05);3年生存率显著提高,差异也有统计学意义(P<0.05)。结论三切口手术可通过有效降低肿瘤细胞增殖和炎性反应而改善食管癌患者的预后。Objective To investigate the effects of cervicothoracic-abdominal three-incision on vascular endothelial growth factor （VEGF）,inflammatory cytokines and to evaluate its mechanism in the patients with middle-upper esophageal cancer.Methods A total of 244 patients with middle-upper esophageal cancer were divided into two groups：experimental group （124 cases） and control group （120 cases）.The post-operative complications,survival rate,serum hypersensitive C-reactive protein （hs-CRP）,interleukin-6 （IL-6）,tumor necrosis factor-α （TNF-α） and VEGF were measured.Results Compared with before operation and control group,the 3-year survival rate in experimental group was significantly increased （P〈0.05）,while the incidence of recent post-operative complications,serum hs-CRP,IL-6,TNF-α and VEGF in experimental group was significantly decreased （P〈0.05）.Conclusion Three-incision operation may improve the prognosis of middle-upper esophageal cancer via reducing proliferation of cancer cells and inflammation.

关 键 词：食管肿瘤 随访研究 吻合术 外科 

分 类 号：R735.1[医药卫生—肿瘤]