KLF4在肝细胞癌中的异常表达  

Study on the Abnormal Expression of KLF4 in the Hepatocellular Carcinoma

作　　者：王长武[1] 

机构地区：[1]郑州大学第五附属医院消化内科,河南郑州450052

出　　处：《慢性病学杂志》2010年第7期580-581,共2页Chronic Pathematology Journal

摘　　要：目的探讨Kruppel样因子4(Kruppel-like factor4,KLF4)与肝细胞癌(Hepatocellular carcinoma,HCC,简称肝癌)发生和发展的关系。方法应用免疫组织化学技术检测KLF4在人正常肝组织、肝硬化组织及肝癌组织中的异常表达,分析KLF4与肝癌发生的可能分子生物学机制。结果免疫组织化学方法证明KLF4在肝癌组织中呈现蛋白质水平的低表达。结论 KLF4作为抑癌基因在肝癌的发生发展中起到相当重要的作用。Objective To explore the relationship between Kruppel-like factor 4（KLF4）and formation and development of hepatocellular carcinoma（HCC）.Methods Using the immunohistochemistry,the abnormal expression of KLF4 was detected in tissues of normal human liver,cirrhosis and HCC.It＇s necessary to investigate the relationship between its expression and development of hepatocellular carcinoma.Furthermore,the possible molecular mechanism of its abnormal expression was explored.Results KLF4 expression was significantly down regulated in HCC immunohistochemistry analysis on protein level.Conclusion KLF4 gives the important role in the carcinogenesis of HCC as an anti-oncogene.

关 键 词：Kruppel样转录因子类/代谢 癌 肝细胞/代谢 

分 类 号：R735.7[医药卫生—肿瘤]