奎硫平与氯氮平对精神分裂症患者疗效及认知功能的影响  

The Cognitive Function of Schizophrenia Patients and Treatment Effects of Quetiapine and Clozapine

作　　者：李莹[1] 王继红[1] 孙群星[1] 曹红军[1] 

机构地区：[1]河南省驻马店市精神病医院,463000

出　　处：《慢性病学杂志》2010年第7期612-613,共2页Chronic Pathematology Journal

摘　　要：目的探讨奎硫平与氯氮平对精神分裂症患者疗效及认知功能的影响。方法符合CCMD-3诊断标准的精神分裂症患者100例,随机分为奎硫平组(50例),氯氮平组(50例),疗程8周。治疗前及8周末分别进行韦氏成人智力量表(WAIS-R)、韦氏记忆量表(WMS)和威斯康星卡片分类测验(WCST)。结果治疗前患者均有认知功能损害,8周后奎硫平与氯氮平两组患者成绩均明显提高。而奎硫平组的改善明显优于氯氮平组。结论认知功能损害是精神分裂症的原发症状之一,奎硫平对其治疗优于氯氮平。Objective To investigate the cognitive function of schizophrenia patients and treatment effects of quetiapine and clozapine.Methods 100 patients with schizophrenia were randomly divided into the quetiapine group（50 patients）,clozapine group（50 patients）.Before treatment and after 8 weeks treatment,Wechsler Adult Intelligence Scale-Revised（WAISR）,Wechsler Memory Scale（WMS）and Wisconsin Card Sorting Test（WCST）were used.Results Before treatment,the patients all have cognitive impairment.After 8 weeks treatment,cognitive function was improved,the quetiapine group improved significantly better than the clozapine group.Conclusions Cognitive impairment is the primary symptom of schizophrenia,the treatment effect of quetiapine was better than clozapine.

关 键 词：二苯硫氮类/治疗应用 氯氮平/治疗应用 精神分裂症/药物疗法 认知 

分 类 号：R749.3[医药卫生—神经病学与精神病学] R971.41[医药卫生—临床医学]