两组药物静脉诱导插管时对脑灌注压的影响  

Comparison of effects on cerebral perfusion pressure during intubation following anesthetic induction by two sets of intravenous drugs

作　　者：卢宝顺[1] 洪原[1] 孙红梅 朱晓波[3] 

机构地区：[1]白求恩医科大学第一临床学院麻醉科,长春市130021 [2]内蒙古兴安盟突泉县妇幼保健院 [3]白求恩医科大学第一临床学院,长春市130021

出　　处：《中华麻醉学杂志》1999年第1期15-17,共3页Chinese Journal of Anesthesiology

摘　　要：目的　脑瘤病人手术时对比硫喷妥钠、琥珀胆碱和依托咪酯、阿曲库铵两组药物诱导麻醉对病人脑灌注压 ( CPP)不同的影响 ;方法　 3 5例择期脑瘤摘除手术病人随机分成硫喷妥钠、琥珀胆碱组 ( 组 ,n=18)和依托咪酯、阿曲库铵组 ( 组 ,n=17) ,于麻醉诱导时应用 HP M 1165 - A多功能脑电监测仪和 Model 12 90 c换能器记录各项参数 ,重点计算 CPP值并进行对比。结果　两组病人在诱导插管期间 CPP均维持正常范围内 ,但 组于注药后 1分和插管后 5分的 CPP均比 组高 ( P<0 .0 5 )。结论　颅内肿瘤病人选用依托咪酯、阿曲库铵麻醉诱导时可降低 ICP,而不降低 CPP,所以比硫喷妥钠。Objective Cerebral perfusion pressure(CPP)of brain tumor patients during induction and tracheal intubation after intravenous sodium pentothal succinylcholine or etomidate atracurium was compared.Methods Thirty five brain tumor patients were randomly divided into sodium pentothal succinylcholine group(group Ⅰ,n=18) and etomidate atracurium group(group Ⅱ,n=17).HP M 1165 A multifunctional monitor and Model 1290c transducer were used to measure the variables and CPP was calculated.Results CPP of both groups during induction were all maintained within normal ranges,but CPP of group Ⅱ,1 min after the administration of the drugs and 5 min after intubation were higher than group Ⅰ.Conclusion ICP decreases after the administration of etomidate atracurium but the CPP unchanges suggesting that this combination used for induction is better than sodium pentothal succinylcholine in patients with brain tumor.

关 键 词：脑血管循环 硫喷妥 琥珀胆碱 依托咪酯 颅内肿瘤 

分 类 号：R739.410.5[医药卫生—肿瘤] R614[医药卫生—临床医学]