双相障碍患者代谢综合征的发生情况及生活方式分析  

The prevalence of metabolic syndrome and lifestyle in bipolar disorder patients

作　　者：关念红[1] 刘海润[1] 张晋碚[1] 张明[1] 吴廷娟[1,2] 

机构地区：[1]中山大学附属第三医院精神科,广州510630 [2]广州医学院第二附属医院精神科

出　　处：《中华行为医学与脑科学杂志》2010年第7期601-603,共3页Chinese Journal of Behavioral Medicine and Brain Science

摘　　要：目的 调查双相障碍患者治疗过程中代谢综合征（MetS）的发生情况并分析其生活方式.方法 收集148例双相障碍患者的体质量指数（BMI）、血糖、血压、甘油三酯（TG）、高密度脂蛋白（HDL-C）等资料,并采用自制量表评估其生活方式,随访6月,与65例正常对照组进行比较.结果 病例组在基线期、治疗1月、3月、6月MetS发生情况分别为：17例（11.5%）、23例（15.5%）、27例（18.2%）、31例（20.9%）;病例组各个阶段MetS、BMI异常、高TG血症、低HDL-C血症、高血压发生率显著高于对照组（P〈0.01）;病例组治疗6月后MetS、高TG血症发生率均显著高于基线期（P〈0.05）;病例组各个阶段MetS发生率显著高于对照组（P〈0.01,P〈0.05）;治疗6月后MetS发生率均显著高于基线期（P〈0.05）.病例组工作强度、体育锻炼频率、每日进食多餐的人数比例与对照组相比均差异有显著性（P〈0.01,P〈0.05）.结论 双相障碍患者代谢综合征发生率高于正常对照组;随着治疗的延续,代谢异常的发生率逐渐上升;不良的生活方式也可能是导致患者出现代谢异常的原因.Objective To explore the prevalence of metabolic syndrome（ MetS） and its components in patients with bipolar disorder and their lifestyle. Methods Collected 148 cases of bipolar disorder in patients with body mass index （BMI）,blood glucose,blood pressure,triglyceride（TG）,high-density lipoprotein（ HDL-C） etc, and self-compiled scale was used to assess their lifestyle. All patients were followed 6 months. The patients werecompared with 65 normal controls. Results The patients group in the baseline period,treatment after 1 months,3 months and 6 months,the incidence of MetS was as followed：11.5% ,15.5% ,18.2% ,20.9%. The patients at all stages,the incidence of MetS,BMI≥25kg/m^2 ,high TG levels,low HDL-C levels and hypertension were significantly higher than the control （P〈0.01）. After 6 months of treatment the incidence of MetS,hypertriglyceridemia were higher than baseline （P 〈 0.05）. The patients group＇ s work intensity, frequency of exercise, eat more than 3 times per day compared with the control group were significantly different （P〈0.01, P〈0.05）. Conclusion The incidence of MetS and hyperuricemia in patients with bipolar disorder after treatment is higher than the control group; as a continuation of the treatment,the incidence of metabolic abnormalities increased gradually. Unhealthy lifestyle, lack of exercise,unreasonable diet maybe increase the risk of metabolic disorders.

关 键 词：双相障碍 代谢综合征 生活方式 

分 类 号：R749.4[医药卫生—神经病学与精神病学]