乳腺癌基因表达谱研究进展  

Advances in gene expression profiling of breast cancer

作　　者：于建刚(综述)[1] 林德馨(审校)[1] 

机构地区：[1]福建医科大学基础医学院生物化学与分子生物学系,福州350014

出　　处：《国际肿瘤学杂志》2010年第4期290-293,共4页Journal of International Oncology

摘　　要：乳腺癌是分子表达差异显著的一组疾病，乳腺癌临床异质性源自分子异质性。根据基因表达谱研究开发的分子标签，如70-基因标签、21-基因标签、乳腺癌分子分型标签等，在预测乳腺癌患者预后、指导临床治疗决策方面，表现出良好的应用价值和前景。Breast cancer should be considered as a family of diseases which are significantly different from each other in molecule level rather than a single disease, and clinical heterogeneity of breast cancer origins from molecular heterogeneity. Gene-expression signatures have been developed based on gene expression profiling of breast cancer, such as the 70- gene signature, 21 - gene signature and intrinsic subtypes of breast cancer. These signatures are valuable and have a good prospect in prognosis predicting and clinical decision of breast cancer.

关 键 词：乳腺肿瘤 基因表达谱 预后 

分 类 号：R737.9[医药卫生—肿瘤]