食管鳞癌组织中P53与P73蛋白表达及其相关性  

Expression and correlation of P73 and P53 proteins in esophagus squamons cell carcinoma

作　　者：杜肖刚[1] 赵素莲[1] 段满乐[2] 

机构地区：[1]山西医科大学微生物与免疫教研室,太原030001 [2]长治医学院附属和平医院检验科

出　　处：《国际肿瘤学杂志》2010年第4期316-319,共4页Journal of International Oncology

摘　　要：目的探讨食管鳞癌组织中P53与1773蛋白的表达及其相关性。方法采用免疫组织化学S—P方法检测46例食管鳞癌组织及30例正常黏膜组织中P53和P73蛋白的表达，并分析两者与相关临床特征的关系及两者之间的相关性。结果在食管鳞癌组织中P53和P73蛋白的表达与其在正常黏膜中的表达差异具有统计学意义（P=0．007，0．008）。P53表达与性别和淋巴转移相关（P=0．047，0．028），而与年龄、分化程度、浸润深度和大体分型无关（P〉0．05）。P73表达与分化程度和淋巴转移相关（P=0．023，0．035）；与年龄、性别、浸润深度和大体分型无关（P〉0．05）。P53和P73在食管鳞癌的表达正相关（r=0．359，P=0．014）。结论P53和P73与食管鳞癌的发生密切相关，而且共同参与食管鳞癌的发展过程。Objective To investigate the expression and correlation of P73 and P53 proteins in esophagus squamous cell carcinoma. Methods The immunohistochemistry staining assay was conducted to detect the expression of P53 and P73 proteins in 46 cases with squamous cell carcinoma of esophagus and 30 normal mucosa cases. The protein expressions and clinic pathological observation and the correlation between two proteins were statistically analyzed. Results The expression of P53 and P73 proteins showed differences between esophageal cancer tissue and normal mucosa （P = 0. 007 , 0. 008 ） . The expression of P53 appeared to be correlated with lymph node metastasis（P = 0.047 ） and gender（ P = 0. 028 ）, but not correlated with age, the depth of invasion, differentiation of cancer tissue, gross observation and position of the tumor（ P 〉 0.05 ）. The expression of P73 appeared to be correlated with differentiation of cancer tissue and lymph node metastasis （ P = 0. 023, 0.035 ） , but not correlated with age, gender, the depth of invasion, gross observation and position of the tumor （P 〉 0.05 ）. P73 expression was positively corelated with P53 expression in squamous cell carcinoma of the e- sophagus （r =0.359 ,P =0.014）. Conclusion Both P73 and P53 proteins are associated with the occurrence of squamous cell carcinoma of the esophagus and participate in the development of esophagus squamous cell carcinoma.

关 键 词：食管肿瘤 癌 鳞状细胞 DNA结合蛋白质类 肿瘤抑制蛋白质P53 

分 类 号：R735.1[医药卫生—肿瘤]