白细胞介素-17与幽门螺杆菌感染所致胃疾病的相关性研究  

Research in the correlation between interleukin-17 and H. pylori-induced gastric diseases

作　　者：刘亚普[1] 张艳[1] 

机构地区：[1]湖南衡阳南华大学病原生物学研究所,衡阳421001

出　　处：《国际免疫学杂志》2010年第4期273-276,共4页International Journal of Immunology

基　　金：湖南省自然科学基金课题资助（06JJ2093）;湖南省教育厅青年基金课题资助（08B067）

摘　　要：幽门螺杆菌（Hp）是导致人类发生慢性活动性胃炎、消化性溃疡的主要病原菌,并且与胃腺癌、胃黏膜相关淋巴组织淋巴瘤的发生也密切相关.Hp诱导产生的白细胞介素-17（IL-17）作为第二信使招致粒细胞在局部聚集,是引起胃部炎症反应以及进一步病理损害的重要调节因子.在Hp感染性胃疾病中,胃粘膜中的IL-17蛋白表达明显增加.Helicobacter pylori （H. pylori or Hp） is the major pathogen which causes human chronic active gastritis and peptic ulcer. Hp is closely related to gastric adenocareinoma, gastric mucosa-associated lymphoid tissue lymphoma. As the second messenger,IL-17 induced by Hp aggregated of granulocyte cells in parts of stomach. IL-17 is an important regulator which causes stomach inflammation and further pathological damages. The expression of IL-17 protein in the gastric mucosa increased significantly in patients with gastric diseases caused by Hp.

关 键 词：IL-17 TH17细胞 幽门螺杆菌 胃疾病 

分 类 号：R573[医药卫生—消化系统]